Safety Data Sheet: Material Name: XYLENE SDS ID: ohs25150 Issue Date: 2016-06-23 Revision: 2.09

                

XYLENE

ChemADVISOR, Inc. Stone Quarry Crossing 811 Camp Horne Road, Suite 220 Pittsburgh, PA 15237 E-mail: info@chemadvisor.com MSDS is for reference use only; please contact manufacturer for emergency response information, routine product inquiries and orders.

hydrocarbons, aromatic 



DIMETHYLBENZENE; DIMETHYL BENZENE; METHYLTOLUENE; METHYL TOLUENE; TOTAL XYLENES; XYLENE (MIXED ISOMERS); XYLENE (MIXED); XYLENES; XYLOL; RCRA U239; UN 1307; C8H10

Emergency Overview 

Color:  colorless or pale 

Change in color: Not available

Physical Form: liquid

Odor:  distinct odor 

Health Hazards:  respiratory tract irritation, skin irritation, eye irritation, aspiration hazard, central nervous system depression 

Physical Hazards:  Flammable liquid and vapor. Vapor may cause flash fire. Electrostatic charges may be generated by flow, agitation, etc. 

Short Term:  irritation, changes in body temperature, nausea, vomiting, stomach pain, chest pain, difficulty breathing, headache, drowsiness, dizziness, disorientation, difficulty speaking, mood swings, tremors, loss of coordination, visual disturbances, lung congestion, kidney damage, liver damage, unconsciousness, coma 

Long Term:  nosebleed, changes in body temperature, nausea, vomiting, stomach pain, loss of appetite, chest pain, difficulty breathing, irregular heartbeat, headache, drowsiness, fatigue, dizziness, disorientation, sleep disturbances, emotional disturbances, mood swings, tremors, loss of coordination, visual disturbances, menstrual disorders, sterility, lung congestion, internal bleeding, blood disorders, heart damage, kidney damage, liver damage, reproductive effects, unconsciousness 

Short Term:  irritation 

Long Term:  irritation 

Short Term:  irritation (possibly severe), sensitivity to light 

Long Term:  irritation, blurred vision, eye damage 

Short Term:  irritation, changes in body temperature, nausea, vomiting, stomach pain, chest pain, difficulty breathing, headache, drowsiness, dizziness, disorientation, difficulty speaking, mood swings, tremors, loss of coordination, visual disturbances, lung congestion, kidney damage, liver damage, unconsciousness, coma, aspiration hazard 

Long Term:  no information on significant adverse effects 

CAS EC No Registration No	Component Name Synonyms	1272/2008 (CLP)	Percent
1330-20-7 215-535-7 --	XYLENE	Flam. Liq. 3 - H226 Acute Tox. 4 (Dermal) - H312 Acute Tox. 4 (Inh.) - H332 Skin Irrit. 2 - H315 Note(s): C	100

If adverse effects occur, remove to uncontaminated area. Give artificial respiration if not breathing. Get immediate medical attention. 



Wash skin with soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention, if needed. Thoroughly clean and dry contaminated clothing and shoes before reuse. 



Flush eyes with plenty of water for at least 15 minutes. Then get immediate medical attention. 



Aspiration hazard. DO NOT induce vomiting. If vomiting occurs, keep head lower than hips to help prevent aspiration. Get immediate medical attention. Give artificial respiration if not breathing. 









See Section 9 for Flammability Properties 



Severe fire hazard. Electrostatic discharges may be generated by flow or agitation resulting in ignition or explosion. The vapor is heavier than air. Vapors or gases may ignite at distant ignition sources and flash back. Vapor/air mixtures are explosive. 



regular dry chemical, carbon dioxide, water, regular foam Large fires: Use regular foam or flood with fine water spray. 



Move container from fire area if it can be done without risk. Cool containers with water spray until well after the fire is out. Stay away from the ends of tanks. For fires in cargo or storage area: Cool containers with water from unmanned hose holder or monitor nozzles until well after fire is out. If this is impossible then take the following precautions: Keep unnecessary people away, isolate hazard area and deny entry. Let the fire burn. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tanks due to fire. For tank, rail car or tank truck: Evacuation radius: 800 meters (1/2 mile). Water may be ineffective. 



oxides of carbon 













Reduce vapors with water spray. Stay upwind and keep out of low areas. 



Trap spilled material at bottom in deep water pockets, excavated holding areas or within sand bag barriers. Dike for later disposal. Absorb with sand or other non-combustible material. Collect with absorbent into suitable container. 



Cover with absorbent sheets, spill-control pads or pillows. Neutralize. Collect with absorbent into suitable container. Absorb with activated carbon. Remove trapped material with suction hoses. Collect spilled material using mechanical equipment. 



Avoid heat, flames, sparks and other sources of ignition. Stop leak if possible without personal risk. Reduce vapors with water spray. Small spills: Absorb with sand or other non-combustible material. Collect spilled material in appropriate container for disposal. Large spills: Dike for later disposal. Remove sources of ignition. Keep unnecessary people away, isolate hazard area and deny entry. Notify Local Emergency Planning Committee and State Emergency Response Commission for release greater than or equal to RQ (U.S. SARA Section 304). If release occurs in the U.S. and is reportable under CERCLA Section 103, notify the National Response Center at (800)424-8802 (USA) or (202)426-2675 (USA). 









Store and handle in accordance with all current regulations and standards. Protect from physical damage. Keep container tightly closed. Store outside or in a detached building. Store with flammable liquids. Store in a cool, dry place. Subject to storage regulations: U.S. OSHA 29 CFR 1910.106. Grounding and bonding required. Keep separated from incompatible substances. 

Component Exposure Limits 

Biological limit value 



Ventilation equipment should be explosion-resistant if explosive concentrations of material are present. Provide local exhaust ventilation system. Ensure compliance with applicable exposure limits. 



Eyes/Face Wear splash resistant safety goggles with a faceshield. Provide an emergency eye wash fountain and quick drench shower in the immediate work area. 



Wear appropriate chemical resistant clothing. 



Wear appropriate chemical resistant gloves. 



polyvinyl alcohol (PVA) 



The following respirators and maximum use concentrations are drawn from NIOSH and/or OSHA. 900 ppm Any air-purifying half-mask respirator equipped with organic vapor cartridge(s). Any powered, air-purifying respirator with organic vapor cartridge(s). Any supplied-air respirator. Any self-contained breathing apparatus with a full facepiece. Emergency or planned entry into unknown concentrations or IDLH conditions - Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Any supplied-air respirator with a full facepiece that is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode. Escape - Any air-purifying full-facepiece respirator (gas mask) with a chin-style, front-mounted or back-mounted organic vapor canister. Any appropriate escape-type, self-contained breathing apparatus. 

Appearance	Not available	Physical State	Liquid
Odor	distinct odor	Color	colorless or pale
Odor Threshold	0.3 ppm	pH	Not available
Melting Point	-48 - 13 °C	Boiling Point	138 - 144 °C
Freezing point	Not available	Evaporation Rate	0.6 (butyl acetate=1)
Boiling Point Range	Not available	Flammability (solid, gas)	Not available
Autoignition	464 - 529 °C	Flash Point	>=25 °C CC
Lower Explosive Limit	1 %	Decomposition	Not available
Upper Explosive Limit	7 %	Vapor Pressure	6 - 16 mmHg at 20 °C
Vapor Density (air=1)	3.7	Specific Gravity (water=1)	0.86 - 0.9
Water Solubility	0.00003 %	Partition coefficient: n-octanol/water	Not available
Viscosity	Not available	Solubility (Other)	Not available
Bioconcentration Factor (BCF)	1216.19	Density	Not available
Henry's Law Constant	2.7896608 atm-m3/mol	KOC	1345860.35 (estimated from water solubility)
Physical Form	liquid	Texture	free-flowing
Volatility	100 %	Molecular Formula	C6-H4-(C-H3)2
Molecular Weight	106.16	OSHA Flammability Class	IC

alcohol, ether, acetone, petroleum ether, benzene, carbon tetrachloride, organic solvents 













Stable at normal temperatures and pressure. 



Avoid heat, flames, sparks and other sources of ignition. Containers may rupture or explode if exposed to heat. Keep out of water supplies and sewers. 



oxidizing materials, combustible materials, acids, amines, bases, 

XYLENE: ACIDS (STRONG): Incompatible AMINES: Incompatible. BASES (STRONG): Incompatible. NITRIC ACID: Exothermic reaction. OXIDIZERS (STRONG): Fire and explosion hazard. PLASTICS, RUBBER, COATINGS: May be attacked. SULFURIC ACID: Exothermic reaction.

oxides of carbon 

Thermal decomposition products: oxides of carbon.

Will not polymerize. 

Component Analysis - LD50/LC50 

Component Carcinogenicity

Alcohol may enhance the toxic effects Stimulants such as epinephrine may induce ventricular fibrillation. 



XYLENE: Irritation of the upper respiratory tract may occur at 200 ppm Exposure to higher concentrations may cause more severe irritation and initial central nervous system excitation followed by depression Signs and symptoms may include respiratory difficulty and substernal pain, transient euphoria, emotional lability, headache, nausea, vomiting, anorexia, abdominal pain, dizziness, drowsiness, ataxia, and staggering There may be salivation, slurred speech, blurred vision, nystagmus, tinnitus, tremors, confusion, and flushing of the face with a feeling of increased body heat In severe exposures, there may be stupor, anesthesia, unconsciousness, and coma which may be punctuated by episodes of neuroirritability, but rarely frank convulsions, except in terminal asphyxia Liver and kidney damage may occur, but are usually mild and transient A group of subjects who inhaled 12.3 umol/L of xylene while exercising became significantly impaired on 3 neuropsychological tests Exposure of 3 painters to approximately 10,000 ppm for 18.5 hours resulted in 1 death from pulmonary edema and petechial brain hemorrhage Both survivors were unconscious for 19-24 hours and experienced retrograde amnesia, hypothermia, and lung congestion Renal and hepatic impairment also developed Complete recovery took 15 days High concentrations may cause death from sudden ventricular fibrillation, but more frequently death occurs from respiratory arrest.



XYLENE: Repeated or prolonged inhalation of vapors above 200 ppm may cause nausea, vomiting, abdominal pain, and anorexia Other common complaints include headache, fatigue, lassitude, irritability, breathing difficulties, and flatulence Effects on the nervous system may result in excitation, followed by depression, paresthesias, tremors, apprehension, impaired memory, insomnia, vertigo, and tinnitus Effects on reaction time, manual coordination, body balance and EEG occurred with repeated exposure to 90 ppm of m-xylene Sweetish taste in the mouth, dry nose and throat, strong thirst, mucosal hemorrhage, and anemia have been reported Effects on the liver, kidney, cardiovascular system, and the bone marrow have also been reported, although the latter has been questioned Exposure of rabbits to 1150 ppm for 40-55 days resulted in a reversible decrease in the red and white cell counts and an increase in the platelets One case of an apparent epileptiform seizure following a relatively brief exposure has occurred Women may develop menstrual disorders, such as menorrhagia or metrorrhagia, infertility, and pathological pregnancy conditions including toxicosis, danger of miscarriage, and hemorrhaging during delivery Repeated exposure of pregnant mice, rats and rabbits to the individual or the mixed isomers has resulted in maternal effects and effects on fertility, on the embryo or fetus, and specific developmental abnormalities Included among these effects are fetal death, fetotoxicity, pre- and post-implantation mortality, abortion, craniofacial and musculoskeletal abnormalities, and extra embryonic structures.



XYLENE: Xylene is a defatting agent and may cause a burning sensation, drying, vasodilation, erythema, and possibly blistering The liquid is readily absorbed through intact or broken skin at a rate of approximately 4-10 mg/cm2/hour, but systemic effects have not been reported.



XYLENE: Repeated or prolonged contact may cause defatting of the skin with drying, erythema, cracking, thickening, and blistering Repeated application of 95% xylene to rabbit skin caused moderate to marked irritation with erythema and moderate necrosis.



XYLENE: Concentrations as low as 200 ppm have caused conjunctival irritation in humans Higher concentrations may produce severe irritation Vapor exposure has also caused tearing and photophobia.



XYLENE: Repeated or prolonged exposure to high vapor concentrations may cause a burning sensation, conjunctivitis, and blurred vision Reversible vacuolar, epithelial keratopathy has been reported in some workers.



XYLENE: Lung damage may occur if aspirated into the lungs and may be fatal Symptoms may include coughing, difficulty breathing, cyanosis, and pulmonary edema May cause a burning sensation in the mouth and stomach, salivation, and severe gastrointestinal distress with nausea and vomiting Depending on exposure levels, hematemesis may also occur with additional toxic effects including central nervous system depression, ventricular fibrillation, liver and kidney injury and other symptoms detailed in acute inhalation Ingestion of small quantities of 90% xylene plus toluene produced urinary dextrose and urobilinogen excretion with toxic hepatitis, which was reversible in 20 days.



XYLENE: Repeated ingestion of mixed xylenes by pregnant mice resulted in effects on fertility, on the embryo or fetus, or specific developmental abnormalities Included among these effects were fetotoxicity, reduced litter size, craniofacial and musculoskeletal system abnormalities, and post-implantation mortality.

Component Analysis - Aquatic Toxicity 

Bioconcentration Factor 

Dispose in accordance with all applicable regulations. Subject to disposal regulations: U.S. EPA 40 CFR 262. Hazardous Waste Number(s): U239. 

Component Waste Numbers 

ADR Tunnel Code Restrictions 

Component Marine Pollutants (IMDG) 

SARA Section 311/312 (40 CFR 370 Subparts B and C) 

Not listed under California Proposition 65 

Germany Water Classification 

REACH List of Substances on Community Rolling Action Plan - Reg. (EU) No. 1907/2006 

The listed component(s) of this material have been checked for country-specific published classifications according to the Globally Harmonized System of Classification and Labeling (GHS). The results of the queries are displayed below. Please see the individual country listings, as additional interpretations or reference information may be available. For a reference list of H- or P-statements, please visit ChemADVISOR’s website at http://www.chemadvisor.com/product-resources/26-pure-substance-and-mixture-databases/247-ghs-hazard-and-physical-statements 

Australia GHS Classifications 

Australia GHS Labeling Information 

European Union GHS Classifications 

European Union GHS Labeling Information 

Indonesia GHS Classifications 

Japan GHS Classifications 

Japan GHS Labeling Information 

Korea GHS Classifications 

Korea GHS Labeling Information 

New Zealand GHS Classifications 

New Zealand GHS Labeling Information 

South Africa GHS Classifications 

Taiwan GHS Classifications 

Taiwan GHS Labeling Information 

No classification assigned. 









ACGIH - American Conference of Governmental Industrial Hygienists; ADR - European Road Transport; AU - Australia; BOD - Biochemical Oxygen Demand; C - Celsius; CA - Canada; CAS - Chemical Abstracts Service; CERCLA - Comprehensive Environmental Response, Compensation, and Liability Act; CN - China; CPR - Controlled Products Regulations; DFG - Deutsche Forschungsgemeinschaft; DOT - Department of Transportation; DSL - Domestic Substances List; EEC - European Economic Community; EINECS - European Inventory of Existing Commercial Chemical Substances; EPA - Environmental Protection Agency; EU - European Union; F - Fahrenheit; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; ICAO - International Civil Aviation Organization; IDL - Ingredient Disclosure List; IDLH - Immediately Dangerous to Life and Health; IMDG - International Maritime Dangerous Goods; JP - Japan; Kow - Octanol/water partition coefficient; KR - Korea; LEL - Lower Explosive Limit; LOLI - List Of LIsts™ - ChemADVISOR’s Regulatory Database; MAK - Maximum Concentration Value in the Workplace; MEL - Maximum Exposure Limits; NFPA - National Fire Protection Agency; NIOSH - National Institute for Occupational Safety and Health; NJTSR - New Jersey Trade Secret Registry; NTP - National Toxicology Program; NZ - New Zealand; OSHA - Occupational Safety and Health Administration; PH - Philippines; RCRA - Resource Conservation and Recovery Act; RID - European Rail Transport; RTECS - Registry of Toxic Effects of Chemical Substances®; SARA - Superfund Amendments and Reauthorization Act; STEL - Short-term Exposure Limit; TDG - Transportation of Dangerous Goods; TSCA - Toxic Substances Control Act; TWA - Time Weighted Average; UEL - Upper Explosive Limit; US - United States 



Reasonable care has been taken in the preparation of this information; however, the manufacturer makes no warranty whatsoever including the warranty of merchantability, expressed or implied, with respect to this information. The manufacturer makes no representations and assumes no liability for any direct, incidental, consequential, or other such damages resulting from its use or misuse.  Supplier gives no warranty whatsoever, including the warranties of merchantability or of fitness for a particular purpose. Any product purchased is sold on the assumption the purchaser shall determine the quality and suitability of the product. Supplier expressly disclaims any and all liability for incidental, consequential or any other damages arising out of the use or misuse of this product. No information provided shall be deemed to be a recommendation to use any product in conflict with any existing patent rights. THIS SDS IS TO BE UTILIZED SOLELY AS A REFERENCE DOCUMENT AND IT IS NOT TO BE USED TO SATISFY THE DISTRIBUTION REQUIREMENTS OF OSHA'S HAZARD COMMUNICATION STANDARD (HCS) NOR CANADA'S CONTROLLED PRODUCT REGULATION (CPR). Read the Safety Data Sheet before handling product. Use of any information contained herein is provided at the reader's own risk and thus independent judgment by trained professionals must be utilized at all times. 







Copyright 1984-2016 ChemADVISOR, Inc "RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through Accelrys/Biovia. Portions ©Copyright 2016, U.S. Government. All rights reserved