2,4-DINITROTOLUENE (TECHNICAL)

INV# 11661

Emergency Overview 

Color:  off-white to yellow 

Change in color: Not available

Physical Form: solid

Odor:  distinct odor 

Health Hazards:  harmful if swallowed, blood damage, suspect cancer hazard (in animals) 

Physical Hazards:  May explode if exposed to shock, friction or heating. 

Short Term:  nausea, vomiting, difficulty breathing, irregular heartbeat, headache, drowsiness, dizziness, bluish skin color, convulsions, coma 

Long Term:  joint pain, visual disturbances, kidney damage, liver damage 

Short Term:  same as effects reported in short term inhalation, irritation (possibly severe), bluish skin color 

Long Term:  same as effects reported in long term inhalation, liver damage 

Short Term:  burns 

Long Term:  no information on significant adverse effects 

Short Term:  same as effects reported in short term inhalation, bluish skin color 

Long Term:  kidney damage, liver damage, paralysis, reproductive effects, cancer 

This product may be regulated, have exposure limits or other information identified as the following: Dinitrotoluene (mixed isomers) (25321-14-6).

If adverse effects occur, remove to uncontaminated area. Give artificial respiration if not breathing. If breathing is difficult, oxygen should be administered by qualified personnel. Get immediate medical attention. 

Cool affected area as quickly as possible by drenching or immersing in water until material solidifies. Do not remove material immediately. Cover area with sterile, dry dressing. Get medical attention immediately. 

Immediately flush eyes with plenty of water for at least 15 minutes. Then get immediate medical attention. 

Contact local poison control center or physician immediately. Never make an unconscious person vomit or drink fluids. When vomiting occurs, keep head lower than hips to help prevent aspiration. If person is unconscious, turn head to side. Get medical attention immediately. 

For inhalation, consider oxygen. For ingestion, consider gastric lavage and activated charcoal slurry. 

See Section 9 for Flammability Properties 

Slight fire hazard. 

regular dry chemical, carbon dioxide, water, regular foam 

Large fires: Use regular foam or flood with fine water spray. 

Move container from fire area if it can be done without risk. Cool containers with water spray until well after the fire is out. Stay away from the ends of tanks. For fires in cargo or storage area: Cool containers with water from unmanned hose holder or monitor nozzles until well after fire is out. If this is impossible then take the following precautions: Keep unnecessary people away, isolate hazard area and deny entry. Let the fire burn. Do not attempt to extinguish fire unless flow of material can be stopped first. Flood with fine water spray. Do not scatter spilled material with high-pressure water streams. Cool containers with water spray until well after the fire is out. Apply water from a protected location or from a safe distance. Avoid inhalation of material or combustion by-products. Stay upwind and keep out of low areas. 

Subject to California Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). Keep out of water supplies and sewers. 

Do not touch spilled material. Stop leak if possible without personal risk. Reduce vapors with water spray. Small spills: Absorb with sand or other non-combustible material. Collect spilled material in appropriate container for disposal. Small dry spills: Move containers away from spill to a safe area. Large spills: Dike for later disposal. Keep unnecessary people away, isolate hazard area and deny entry. Ventilate closed spaces before entering. Notify Local Emergency Planning Committee and State Emergency Response Commission for release greater than or equal to RQ (U.S. SARA Section 304). If release occurs in the U.S. and is reportable under CERCLA Section 103, notify the National Response Center at (800)424-8802 (USA) or (202)426-2675 (USA). 

Store and handle in accordance with all current regulations and standards. Keep separated from incompatible substances. 

Component Exposure Limits 

Biological limit value 

Provide local exhaust or process enclosure ventilation system. Ventilation equipment should be explosion-resistant if explosive concentrations of material are present. Ensure compliance with applicable exposure limits. 

Eyes/Face Wear splash resistant safety goggles with a faceshield. Provide an emergency eye wash fountain and quick drench shower in the immediate work area. 

Wear appropriate chemical resistant clothing. 

Wear appropriate chemical resistant gloves. 

The following respirators and maximum use concentrations are drawn from NIOSH and/or OSHA. At any detectable concentration - Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Any supplied-air respirator with a full facepiece that is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode. Escape - Any air-purifying full-facepiece respirator (gas mask) with a chin-style, front-mounted or back-mounted organic vapor canister having an N100, R100, or P100 filter. Any appropriate escape-type, self-contained breathing apparatus. For Unknown Concentrations or Immediately Dangerous to Life or Health - Any supplied-air respirator with a full facepiece that is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode. Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. 

May decompose explosively when heated above 280 C. May explode if exposed to shock, friction or heating. 

bases, metals, oxidizing materials, reducing agents, metal oxides 

2,4-DINITROTOLUENE CAUSTICS: May cause evolution of heat and increase in pressure. METALS (ACTIVE): May cause evolution of heat and increase in pressure. NITRIC ACID: Explosion. OXIDIZERS (STRONG): Fire and explosion hazard. REDUCING AGENTS (STRONG): Fire and explosion hazard. SODIUM OXIDE: Rapid reaction with possible fire. 2,6-DINITROTOLUENE CAUSTICS: May cause evolution of heat and increase in pressure. METALS (ACTIVE): May cause evolution of heat and increase in pressure. NITRIC ACID: Explosive mixture. OXIDIZERS (STRONG): Fire and explosion hazard. REDUCING AGENTS (STRONG): Fire and explosion hazard. SODIUM OXIDE: Rapid reaction with possible fire.

oxides of nitrogen 

Thermal decomposition products: oxides of nitrogen. 

Will not polymerize. 

Component Analysis - LD50/LC50 

Component Carcinogenicity

A cohort Study found an increased risk for cancer of the liver and gall-bladder among workers exposed to a mixture of 2,4-dinitrotoluene and 2,6-dinitrotoluene, but no such increase was observed in previous studies, and therefore was not considered to be strong or consist enough to permit a conclusion of a carcinogen to humans In oral administration studies mice were observed with tumors of the renal tubular epithelium, while male rats were observed with various tumors of the integumentary system Female rats were observed with increased incidence of fibroadenomas, and both male and female rats were observed with an increased incidence of hepatocellular carcinomas A cohort study found an increased risk for cancer of the liver and gall-bladder among workers exposed to a mixture of 2,4-dinitrotoluene and 2,6-dinitrotoluene, but no such increase was observed in previous studies and therefore were not considered to be strong or consist enough to permit a conclusion on the carcinogenicity in humans In oral administration studies with male rats, increased incidences of hepatocellular neoplastic nodules and carcinomas were observed. 

blood system disorders, blood system disorders, heart or cardiovascular disorders, heart or cardiovascular disorders, 

Alcohol may enhance the toxic effects Alcohol may enhance the toxic effects. 

Higher ambient temperatures increase the susceptibility to cyanosis Reduced sperm counts, effects on sperm morphology, and spontaneous abortions in workers' wives have been reported for workers with occupational exposure to technical grade DNT, but the results of the studies are equivocal Higher ambient temperatures increase the susceptibility to cyanosis Reduced sperm counts, effects on sperm morphology, and spontaneous abortion in workers' wives have been reported for workers with occupational exposure to technical grade DNT, but the results of the studies are equivocal. 

2,4-DINITROTOLUENE: Inhalation of dust or fumes may cause methemoglobinemia At a methemoglobin level of 15%, the worker may experience cyanosis, headache, euphoria, and flushed face 25-40% may cause shortness of breath upon exertion 40-60% may cause weakness, dizziness, lightheadedness, severe headache, ataxia, shallow respiration, drowsiness, nausea, vomiting, confusion, lethargy and stupor Higher levels may cause tachycardia, convulsions, coma, and death Onset of symptoms may be delayed for up to 4 hours 2,6-DINITROTOLUENE: Inhalation of dust or fumes may cause methemoglobinemia At a methemoglobin level of 15%, the worker may experience cyanosis, headache, euphoria, and flushed face 25-40% may cause shortness of breath upon exertion 40-60% may cause weakness, dizziness, lightheadedness, severe headache, ataxia, shallow respiration, drowsiness, nausea, vomiting, confusion, lethargy, and stupor Higher levels may cause tachycardia, convulsions, coma, and death Onset of symptoms may be delayed for up to 4 hours.

2,4-DINITROTOLUENE: Repeated or prolonged exposure to dinitrotoluene may cause anemia, Heinz bodies, reticulocytosis, leukopenia, pallor, cyanosis, arthralgia, headache, dizziness, nausea, anorexia, weakness, giddiness, fatigue and insomnia Other symptoms may include an unpleasant taste, nystagmus, and tingling pain in the extremities Liver or kidney damage may also occur Exposure to technical grade DNT, which contains the 2,4-isomer, has also caused tremors and impaired reflexes; workers exposed for more than 15 years experienced a significant increase in the death rate due to ischemic heart disease and residual diseases of the circulatory system 2,6-DINITROTOLUENE: Repeated or prolonged exposure to dinitrotoluene may cause anemia, Heinz bodies, reticulocytosis, leukopenia, pallor, cyanosis, arthralgia, headache, dizziness, nausea, anorexia, weakness, giddiness, fatigue, insomnia, and nystagmus Liver and kidney damage may also occur Exposure to technical grade DNT, which contains the 2,6-isomer, has also caused tremors and impaired reflexes; workers exposed for more than 15 years experienced a significant increase in the death rate due to ischemic heart disease and other residual diseases of the circulatory system.

2,4-DINITROTOLUENE: May cause mild irritation Contact with the molten material may cause thermal burns Absorption through intact skin may cause methemoglobinemia with symptoms as described in acute inhalation 5 grams applied twice to cat skin caused death within 8 hours 2,6-DINITROTOLUENE: May cause mild irritation Contact with the molten material may cause thermal burns Absorption through intact skin may cause methemoglobinemia with symptoms as described in acute inhalation.

2,4-DINITROTOLUENE: Repeated or prolonged exposure may cause dermatitis and turn the skin yellow Anemia, liver damage, and other symptoms of systemic toxicity as described in chronic inhalation may also occur 2,6-DINITROTOLUENE: Repeated or prolonged exposure may cause dermatitis and turn the skin yellow Anemia, liver damage, and other symptoms of systemic toxicity as described in chronic inhalation may also occur Mild sensitization was reported in guinea pigs.

2,4-DINITROTOLUENE: Solid material is reported to be nonirritating in rabbit eyes Contact with the molten material may cause thermal burns The hot fumes have caused a severe burn of the cornea and eyelid with permanent scarring 2,6-DINITROTOLUENE: Solid material is reported to be nonirritating in rabbit eyes Contact with the molten material may cause thermal burns The hot fumes have caused a severe burn of the cornea and eyelid with permanent scarring.

2,4-DINITROTOLUENE: No data available 2,6-DINITROTOLUENE: No data available.

2,4-DINITROTOLUENE: Ingestion may cause the formation of methemoglobin with symptoms as described in acute inhalation Additional signs of toxicity reported in animal studies include muscular incoordination and central nervous system and respiratory depression followed by death 2,6-DINITROTOLUENE: Ingestion may cause methemoglobinemia with symptoms as described in acute inhalation Additional signs of toxicity reported in animal studies include muscular incoordination and central nervous system and respiratory depression followed by death.

2,6-DINITROTOLUENE: In animal studies, repeated ingestion has caused liver and kidney damage, anemia, incoordination, and paralysis Ingestion of 2,6-dinitrotoluene for 2 years by several animal species has caused decreased spermatogenesis, aspermatogenesis, testicular atrophy or or nonfunctioning of the ovaries In oral administration studies with male rats, increased incidences of hepatocellular neoplastic nodules and carcinomas were observed A technical grade of dinitrotoluene, (approximately 80/20, 2,4-dinitrotoluene and 2,6-dinitrotoluene) was tested in two studies producing hepatocellular neoplastic nodules and hepatocellular carcinomas in male rats in one study and in both sexes in the second study 2,4-DINITROTOLUENE: In animal studies, repeated ingestion has caused liver and kidney damage, anemia, incoordination, and paralysis Repeated ingestion by several animal species has also caused reproductive effects including reduced sperm production, testicular and ovarian atrophy, and reduced neonatal viability Administration of 2,4-DNT with 2% 2,6-DNT, a potent hepatocarcinogen, for 2 years has produced renal tumors in male, but not female, mice at 97 mg/kg/day, and liver tumors in rats at 40 mg/kg/day 2 year and 78 week studies in rats reported significant increases in subcutaneous tissue fibromas in males and mammary gland fibroadenomas in females In oral administration studies with mice, male mice with the higher dosage were observed with tumors of the renal tubular epithelium In two other oral administration studies with rats, males were observed with increased incidences of various tumors of the integumentary system, the females were observed with increased incidence of fibroadenomas of the mammory gland, and in both sexes increased incidences of hepatocellular carcinomas were observed In a separate gavage study, the administration of technical grade 2,4-dinitrotoluene induced adverse reproductive effects and anti-spermatogenic activity.

Component Analysis - Aquatic Toxicity 

Bioconcentration Factor 

Dispose in accordance with all applicable regulations. 

Component Waste Numbers 

Component Marine Pollutants 

ADR Tunnel Code Restrictions 

Component Marine Pollutants (IMDG) 

SARA Section 311/312 (40 CFR 370 Subparts B and C) 

The following statement(s) are provided under the California Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65): 

Canadian WHMIS Ingredient Disclosure List (IDL) 

Germany Water Classification 

REACH Candidate List of Substances Subject to Authorization (Article 59(1)) - Reg. (EU) No. 1907/2006 

REACH List of Substances Subject to Authorization (Annex XIV) - Reg. (EU) No. 1907/2006 

REACH List of Substances Subject to Restriction (Annex XVII) - Reg. (EU) No. 1907/2006 

The listed component(s) of this material have been checked for country-specific published classifications according to the Globally Harmonized System of Classification and Labeling (GHS). The results of the queries are displayed below. Please see the individual country listings, as additional interpretations or reference information may be available. For a reference list of H- or P-statements, please visit ChemADVISOR’s website at http://www.chemadvisor.com/product-resources/26-pure-substance-and-mixture-databases/247-ghs-hazard-and-physical-statements 

Australia GHS Classifications 

Australia GHS Labeling Information 

European Union GHS Classifications 

European Union GHS Labeling Information 

Indonesia GHS Classifications 

Japan GHS Classifications 

Japan GHS Labeling Information 

Korea GHS Classifications 

Korea GHS Labeling Information 

New Zealand GHS Classifications 

South Africa GHS Classifications 

Taiwan GHS Classifications 

Taiwan GHS Labeling Information 

No classification assigned. 

ACGIH - American Conference of Governmental Industrial Hygienists; ADR - European Road Transport; AU - Australia; BOD - Biochemical Oxygen Demand; C - Celsius; CA - Canada; CAS - Chemical Abstracts Service; CERCLA - Comprehensive Environmental Response, Compensation, and Liability Act; CN - China; CPR - Controlled Products Regulations; DFG - Deutsche Forschungsgemeinschaft; DOT - Department of Transportation; DSL - Domestic Substances List; EEC - European Economic Community; EINECS - European Inventory of Existing Commercial Chemical Substances; EPA - Environmental Protection Agency; EU - European Union; F - Fahrenheit; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; ICAO - International Civil Aviation Organization; IDL - Ingredient Disclosure List; IDLH - Immediately Dangerous to Life and Health; IMDG - International Maritime Dangerous Goods; JP - Japan; Kow - Octanol/water partition coefficient; KR - Korea; LEL - Lower Explosive Limit; LOLI - List Of LIsts™ - ChemADVISOR’s Regulatory Database; MAK - Maximum Concentration Value in the Workplace; MEL - Maximum Exposure Limits; NFPA - National Fire Protection Agency; NIOSH - National Institute for Occupational Safety and Health; NJTSR - New Jersey Trade Secret Registry; NTP - National Toxicology Program; NZ - New Zealand; OSHA - Occupational Safety and Health Administration; PH - Philippines; RCRA - Resource Conservation and Recovery Act; RID - European Rail Transport; RTECS - Registry of Toxic Effects of Chemical Substances®; SARA - Superfund Amendments and Reauthorization Act; STEL - Short-term Exposure Limit; TDG - Transportation of Dangerous Goods; TSCA - Toxic Substances Control Act; TWA - Time Weighted Average; UEL - Upper Explosive Limit; US - United States 

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Supplier gives no warranty whatsoever, including the warranties of merchantability or of fitness for a particular purpose. Any product purchased is sold on the assumption the purchaser shall determine the quality and suitability of the product. Supplier expressly disclaims any and all liability for incidental, consequential or any other damages arising out of the use or misuse of this product. No information provided shall be deemed to be a recommendation to use any product in conflict with any existing patent rights. THIS SDS IS TO BE UTILIZED SOLELY AS A REFERENCE DOCUMENT AND IT IS NOT TO BE USED TO SATISFY THE DISTRIBUTION REQUIREMENTS OF OSHA'S HAZARD COMMUNICATION STANDARD (HCS) NOR CANADA'S CONTROLLED PRODUCT REGULATION (CPR). Read the Safety Data Sheet before handling product. Use of any information contained herein is provided at the reader's own risk and thus independent judgment by trained professionals must be utilized at all times. 

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