4-NITROBIPHENYL

aromatic 

4-NITRODIPHENYL; P-NITROBIPHENYL; P-PHENYL-NITROBENZENE; P-NITRODIPHENYL; 4-PHENYL-NITROBENZENE; PNB

Emergency Overview 

Color:  white to yellow 

Change in color: Not available

Physical Form: crystals

Odor:  sweet odor 

Health Hazards:  eye irritation 

Short Term:  no information is available 

Long Term:  headache, dizziness, bluish skin color 

Short Term:  irritation 

Long Term:  same as effects reported in short term exposure 

Short Term:  irritation, tearing, eye damage 

Long Term:  same as effects reported in short term exposure 

Short Term:  no information is available 

Long Term:  cancer 

If adverse effects occur, remove to uncontaminated area. Give artificial respiration if not breathing. Get immediate medical attention. 

Wash skin with soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention, if needed. Thoroughly clean and dry contaminated clothing and shoes before reuse. 

Flush eyes with plenty of water for at least 15 minutes. Then get immediate medical attention. 

Contact local poison control center or physician immediately. Never make an unconscious person vomit or drink fluids. When vomiting occurs, keep head lower than hips to help prevent aspiration. If person is unconscious, turn head to side. Get medical attention immediately. 

For ingestion, consider gastric lavage and activated charcoal slurry. 

See Section 9 for Flammability Properties 

Slight fire hazard. 

regular dry chemical, carbon dioxide, water, regular foam Large fires: Use regular foam or flood with fine water spray. 

Move container from fire area if it can be done without risk. Do not scatter spilled material with high-pressure water streams. Dike for later disposal. Use extinguishing agents appropriate for surrounding fire. Avoid inhalation of material or combustion by-products. Stay upwind and keep out of low areas. 

Subject to California Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). Keep out of water supplies and sewers. 

Collect spilled material in appropriate container for disposal. Keep out of water supplies and sewers. Keep unnecessary people away, isolate hazard area and deny entry. Notify Local Emergency Planning Committee and State Emergency Response Commission for release greater than or equal to RQ (U.S. SARA Section 304). If release occurs in the U.S. and is reportable under CERCLA Section 103, notify the National Response Center at (800)424-8802 (USA) or (202)426-2675 (USA). 

OSHA 29 CFR 1910.1003 requires that employees engaged in handling operations must be provided with, and required to wear and use a half-face filter-type respirator with filters for dusts, mists, and fumes, or air-purifying canisters or cartridges. A respirator affording higher levels of protection may be substituted. 

Store and handle in accordance with all current regulations and standards. Keep separated from incompatible substances. 

Component Exposure Limits 

Biological limit value 

Provide local exhaust ventilation system. Ensure compliance with applicable exposure limits. 

Eyes/Face Wear splash resistant safety goggles. Provide an emergency eye wash fountain and quick drench shower in the immediate work area. 

Wear appropriate chemical resistant clothing. 

Wear appropriate chemical resistant gloves. OSHA REGULATED SUBSTANCES: U.S. OSHA 29 CFR 1910.1003. 

The following respirators and maximum use concentrations are drawn from NIOSH and/or OSHA. OSHA Standard: Respirator selection should comply with 29 CFR 1910.134, 29 CFR 1910.1003, and the final rule published in the Federal Register on August 24, 2006. NIOSH Recommendations: At any detectable concentration - Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Any supplied-air respirator with a full facepiece that is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode. Escape - Any air-purifying, full-facepiece respirator equipped with an N100, R100, or P100 filter. Any appropriate escape-type, self-contained breathing apparatus. 

benzene, chloroform, ether 

Stable at normal temperatures and pressure. 

Avoid heat, flames, sparks and other sources of ignition. Avoid contact with incompatible materials. 

reducing agents, 

4-NITROBIPHENYL: STRONG REDUCERS: Incompatible

oxides of carbon, nitrogen 

Thermal decomposition products: oxides of carbon, nitrogen. test.

Will not polymerize. 

Component Analysis - LD50/LC50 

Component Carcinogenicity

Carcinomas of the bladder were induced when given orally to dogs. 

4-NITROBIPHENYL No data available.

4-NITROBIPHENYL: No reports on the carcinogenicity of 4-nitrobiphenyl in man have been reported However, 4-nitrobiphenyl can be converted to 4-aminobiphenyl, a recognized Human Carcinogen A high incidence of bladder cancer has been observed in workers exposed to 4-aminobiphenyl Chronic exposure to nitro compounds of aromatic hydrocarbons may cause anemia, moderate cyanosis, fatigue, dizziness, headache, insomnia, loss of weight and damage to the liver and kidneys.

4-NITROBIPHENYL: May be absorbed through the skin Contact with aromatic hydrocarbons may cause irritation.

4-NITROBIPHENYL: No cases of carcinogenicity in man have been reported However, 4-nitrobiphenyl can be converted to 4-aminobiphenyl, a recognized Human Carcinogen A high incidence of bladder cancer has been observed in workers exposed to 4-aminobiphenyl Repeated or prolonged exposure to aromatic hydrocarbons may cause dermatitis As with other nitro compounds of aromatic hydrocarbons, if sufficient amounts are absorbed, systemic toxicity may occur as detailed in chronic inhalation.

4-NITROBIPHENYL: May cause irritation and possible corneal damage Aromatic hydrocarbons may cause lacrimation.

4-NITROBIPHENYL Repeated or prolonged exposure to irritants may cause conjunctivitis.

4-NITROBIPHENYL No data available.

4-NITROBIPHENYL Repeated feedings of 300 mg, 3 times a week for 33 months, induced carcinomas of the bladder epithelium in 2 of 4 dogs tested.

Component Analysis - Aquatic Toxicity 

Dispose in accordance with all applicable regulations. 

Component Waste Numbers 

Component Marine Pollutants (IMDG) 

SARA Section 311/312 (40 CFR 370 Subparts B and C) 

The following statement(s) are provided under the California Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65): 

Canadian WHMIS Ingredient Disclosure List (IDL) 

REACH List of Substances Subject to Restriction (Annex XVII) - Reg. (EU) No. 1907/2006 

The listed component(s) of this material have been checked for country-specific published classifications according to the Globally Harmonized System of Classification and Labeling (GHS). The results of the queries are displayed below. Please see the individual country listings, as additional interpretations or reference information may be available. For a reference list of H- or P-statements, please visit ChemADVISOR’s website at http://www.chemadvisor.com/product-resources/26-pure-substance-and-mixture-databases/247-ghs-hazard-and-physical-statements 

Australia GHS Classifications 

Australia GHS Labeling Information 

European Union GHS Classifications 

European Union GHS Labeling Information 

Indonesia GHS Classifications 

Japan GHS Classifications 

Japan GHS Labeling Information 

Korea GHS Classifications 

Korea GHS Labeling Information 

New Zealand GHS Classifications 

South Africa GHS Classifications 

Taiwan GHS Classifications 

Taiwan GHS Labeling Information 

No classification assigned. 

ACGIH - American Conference of Governmental Industrial Hygienists; ADR - European Road Transport; AU - Australia; BOD - Biochemical Oxygen Demand; C - Celsius; CA - Canada; CAS - Chemical Abstracts Service; CERCLA - Comprehensive Environmental Response, Compensation, and Liability Act; CN - China; CPR - Controlled Products Regulations; DFG - Deutsche Forschungsgemeinschaft; DOT - Department of Transportation; DSL - Domestic Substances List; EEC - European Economic Community; EINECS - European Inventory of Existing Commercial Chemical Substances; EPA - Environmental Protection Agency; EU - European Union; F - Fahrenheit; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; ICAO - International Civil Aviation Organization; IDL - Ingredient Disclosure List; IDLH - Immediately Dangerous to Life and Health; IMDG - International Maritime Dangerous Goods; JP - Japan; Kow - Octanol/water partition coefficient; KR - Korea; LEL - Lower Explosive Limit; LOLI - List Of LIsts™ - ChemADVISOR’s Regulatory Database; MAK - Maximum Concentration Value in the Workplace; MEL - Maximum Exposure Limits; NFPA - National Fire Protection Agency; NIOSH - National Institute for Occupational Safety and Health; NJTSR - New Jersey Trade Secret Registry; NTP - National Toxicology Program; NZ - New Zealand; OSHA - Occupational Safety and Health Administration; PH - Philippines; RCRA - Resource Conservation and Recovery Act; RID - European Rail Transport; RTECS - Registry of Toxic Effects of Chemical Substances®; SARA - Superfund Amendments and Reauthorization Act; STEL - Short-term Exposure Limit; TDG - Transportation of Dangerous Goods; TSCA - Toxic Substances Control Act; TWA - Time Weighted Average; UEL - Upper Explosive Limit; US - United States 

Reasonable care has been taken in the preparation of this information; however, the manufacturer makes no warranty whatsoever including the warranty of merchantability, expressed or implied, with respect to this information. The manufacturer makes no representations and assumes no liability for any direct, incidental, consequential, or other such damages resulting from its use or misuse. 

Supplier gives no warranty whatsoever, including the warranties of merchantability or of fitness for a particular purpose. Any product purchased is sold on the assumption the purchaser shall determine the quality and suitability of the product. Supplier expressly disclaims any and all liability for incidental, consequential or any other damages arising out of the use or misuse of this product. No information provided shall be deemed to be a recommendation to use any product in conflict with any existing patent rights. THIS SDS IS TO BE UTILIZED SOLELY AS A REFERENCE DOCUMENT AND IT IS NOT TO BE USED TO SATISFY THE DISTRIBUTION REQUIREMENTS OF OSHA'S HAZARD COMMUNICATION STANDARD (HCS) NOR CANADA'S CONTROLLED PRODUCT REGULATION (CPR). Read the Safety Data Sheet before handling product. Use of any information contained herein is provided at the reader's own risk and thus independent judgment by trained professionals must be utilized at all times. 

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