URACIL MUSTARD

pyrimidines, halogens 

5-(BIS(2-CHLOROETHYL)AMINO)-2,4(1H,3H)-PYRIMIDINEDIONE; 5-(BIS(2-CHLOROETHYL)AMINO)-URACIL; AMINOURACIL MUSTARD; CHLORETHAMINACIL; DEMETHYLDOPAN; DESMETHYLDOPAN; ENT 50439; NORDOPAN; U-8344; URACILLOST; URAMUSTIN; URAMUSTINE; RCRA U237

Emergency Overview 

Color:  off-white, white 

Change in color: Not available

Physical Form: crystalline powder, crystals

Odor:  odorless 

Health Hazards:  potentially fatal if swallowed, suspect cancer hazard (in animals) 

Physical Hazards:  May react on contact with water. 

Short Term:  lung congestion 

Long Term:  no information is available 

Short Term:  irritation (possibly severe), hair loss 

Long Term:  no information is available 

Short Term:  irritation, eye damage 

Long Term:  no information is available 

Short Term:  hair loss, nausea, vomiting, diarrhea, menstrual disorders, blood disorders, kidney damage, death 

Long Term:  no information on significant adverse effects 

If adverse effects occur, remove to uncontaminated area. Give artificial respiration if not breathing. Get immediate medical attention. 

Wash skin with soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention, if needed. Thoroughly clean and dry contaminated clothing and shoes before reuse. 

Flush eyes with plenty of water for at least 15 minutes. Then get immediate medical attention. 

If a large amount is swallowed, get medical attention. 

See Section 9 for Flammability Properties 

Negligible fire hazard. 

regular dry chemical, carbon dioxide, water, regular foam Large fires: Use regular foam or flood with fine water spray. 

Move container from fire area if it can be done without risk. Avoid inhalation of material or combustion by-products. Stay upwind and keep out of low areas. 

Subject to California Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). Keep out of water supplies and sewers. 

Do not touch spilled material. Stop leak if possible without personal risk. Small spills: Absorb with sand or other non-combustible material. Collect with absorbent into suitable container. Small dry spills: Collect spilled material in appropriate container for disposal. Move containers away from spill to a safe area. Large spills: Dike for later disposal. Keep unnecessary people away, isolate hazard area and deny entry. Notify Local Emergency Planning Committee and State Emergency Response Commission for release greater than or equal to RQ (U.S. SARA Section 304). If release occurs in the U.S. and is reportable under CERCLA Section 103, notify the National Response Center at (800)424-8802 (USA) or (202)426-2675 (USA). 

Store and handle in accordance with all current regulations and standards. 

Component Exposure Limits 

Biological limit value 

Provide local exhaust or process enclosure ventilation system. Ensure compliance with applicable exposure limits. 

Eyes/Face Wear splash resistant safety goggles. Provide an emergency eye wash fountain and quick drench shower in the immediate work area. 

Wear appropriate chemical resistant clothing. 

Wear appropriate chemical resistant gloves. 

Under conditions of frequent use or heavy exposure, respiratory protection may be needed. Respiratory protection is ranked in order from minimum to maximum. Consider warning properties before use. Any supplied-air respirator with a full facepiece that is operated in a pressure-demand or other positive-pressure mode. Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. For Unknown Concentrations or Immediately Dangerous to Life or Health - Any supplied-air respirator with a full facepiece that is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode. Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. 

methanol, acetone, dimethylacetamide 

benzene, chloroform 

May react on contact with water. 

Avoid heat, flames, sparks and other sources of ignition. Avoid generating dust. Keep out of water supplies and sewers. 

acids 

URACIL MUSTARD: ACID SOLUTIONS: Unstable.

oxides of nitrogen, acid halides 

Thermal decomposition products: oxides of nitrogen, hydrogen chloride.

Will not polymerize. 

Component Analysis - LD50/LC50 

Component Carcinogenicity

Uracil mustard is carcinogenic in mice and rats following its intraperitoneal injection, producing a dose-related increase in the incidence of lung tumors in mice and a variety of tumors in both mice and rats. 

URACIL MUSTARD: Industrially, irritation of the mucous membranes has occurred following exposure to nitrogen mustard vapors Delayed pulmonary edema following accidental vapor exposure has been reported Nitrogen mustards are absorbed through the respiratory tract in sufficient amounts to produce systemic intoxication.

URACIL MUSTARD No data available.

URACIL MUSTARD: Vapors may cause skin irritation In contact with the skin, the nitrogen mustards are severely vesicant and damaging However, there is one report on uracil mustard that states that the drug is not a vesicant Accidental burns of human skin leading to deep and slow-to-heal ulcers has been reported with nitrogen mustards They are absorbed through the skin in sufficient amounts to produce systemic intoxication Bone marrow depression may be observed following application of nitrogen mustards with leukopenia and bleeding Alopecia may occur They can cause impairment of mensis and spermatogenesis.

URACIL MUSTARD No data available.

URACIL MUSTARD: Vapors may cause irritation Upon contact with the eye, nitrogen mustard are severely vesicant and damaging Accidental corneal damage including injury of the iris and lens have been reported.

URACIL MUSTARD No data available.

URACIL MUSTARD: May cause nausea, vomiting, diarrhea, partial alopecia, pruritus, dermatitis and hematopoietic depression Nervousness, irritability, depression, amenorrhea and oligospermia may occur infrequently Bone-marrow depression with leukopenia, thrombocytopenia and even anemia may occur Rapid involution of tumors may cause hyperuricemia and consequent nephropathy and renal failure In a study, uracil mustard induced extensive damage in rat bone marrow and testes and at higher doses caused hepatic changes At doses of 0.3 and 0.6 mg/kg administered to females on day 12 of gestation extensive malformations in surviving offspring were caused Nitrogen mustards are absorbed through the gastrointestinal tract in sufficient amounts to produce systemic intoxication Cytotoxic agents may cause a decreased resistance to infection caused by granulocytopenia and suppression of the immune response results in a host of opportunistic infections The embryo and fetus are highly susceptible to cytotoxic agents Acutely toxic doses may cause cellular death and result in fetal death Survivors may show symptoms of damage to systems that contain cells in cycle and with a short cycle time.

URACIL MUSTARD Repeated or prolonged administration of low doses of cytotoxic agents may produce cellular abnormalities in several systems.

Component Analysis - Aquatic Toxicity 

Dispose in accordance with all applicable regulations. Subject to disposal regulations: U.S. EPA 40 CFR 262. Hazardous Waste Number(s): U237. 

Component Waste Numbers 

Component Marine Pollutants (IMDG) 

SARA Section 311/312 (40 CFR 370 Subparts B and C) 

The following statement(s) are provided under the California Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65): 

The listed component(s) of this material have been checked for country-specific published classifications according to the Globally Harmonized System of Classification and Labeling (GHS). The results of the queries are displayed below. Please see the individual country listings, as additional interpretations or reference information may be available. For a reference list of H- or P-statements, please visit ChemADVISOR’s website at http://www.chemadvisor.com/product-resources/26-pure-substance-and-mixture-databases/247-ghs-hazard-and-physical-statements 

Australia GHS Classifications 

European Union GHS Classifications 

Indonesia GHS Classifications 

Japan GHS Classifications 

Korea GHS Classifications 

New Zealand GHS Classifications 

South Africa GHS Classifications 

Taiwan GHS Classifications 

No classification assigned. 

ACGIH - American Conference of Governmental Industrial Hygienists; ADR - European Road Transport; AU - Australia; BOD - Biochemical Oxygen Demand; C - Celsius; CA - Canada; CAS - Chemical Abstracts Service; CERCLA - Comprehensive Environmental Response, Compensation, and Liability Act; CN - China; CPR - Controlled Products Regulations; DFG - Deutsche Forschungsgemeinschaft; DOT - Department of Transportation; DSL - Domestic Substances List; EEC - European Economic Community; EINECS - European Inventory of Existing Commercial Chemical Substances; EPA - Environmental Protection Agency; EU - European Union; F - Fahrenheit; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; ICAO - International Civil Aviation Organization; IDL - Ingredient Disclosure List; IDLH - Immediately Dangerous to Life and Health; IMDG - International Maritime Dangerous Goods; JP - Japan; Kow - Octanol/water partition coefficient; KR - Korea; LEL - Lower Explosive Limit; LOLI - List Of LIsts™ - ChemADVISOR’s Regulatory Database; MAK - Maximum Concentration Value in the Workplace; MEL - Maximum Exposure Limits; NFPA - National Fire Protection Agency; NIOSH - National Institute for Occupational Safety and Health; NJTSR - New Jersey Trade Secret Registry; NTP - National Toxicology Program; NZ - New Zealand; OSHA - Occupational Safety and Health Administration; PH - Philippines; RCRA - Resource Conservation and Recovery Act; RID - European Rail Transport; RTECS - Registry of Toxic Effects of Chemical Substances®; SARA - Superfund Amendments and Reauthorization Act; STEL - Short-term Exposure Limit; TDG - Transportation of Dangerous Goods; TSCA - Toxic Substances Control Act; TWA - Time Weighted Average; UEL - Upper Explosive Limit; US - United States 

Reasonable care has been taken in the preparation of this information; however, the manufacturer makes no warranty whatsoever including the warranty of merchantability, expressed or implied, with respect to this information. The manufacturer makes no representations and assumes no liability for any direct, incidental, consequential, or other such damages resulting from its use or misuse. 

Supplier gives no warranty whatsoever, including the warranties of merchantability or of fitness for a particular purpose. Any product purchased is sold on the assumption the purchaser shall determine the quality and suitability of the product. Supplier expressly disclaims any and all liability for incidental, consequential or any other damages arising out of the use or misuse of this product. No information provided shall be deemed to be a recommendation to use any product in conflict with any existing patent rights. THIS SDS IS TO BE UTILIZED SOLELY AS A REFERENCE DOCUMENT AND IT IS NOT TO BE USED TO SATISFY THE DISTRIBUTION REQUIREMENTS OF OSHA'S HAZARD COMMUNICATION STANDARD (HCS) NOR CANADA'S CONTROLLED PRODUCT REGULATION (CPR). Read the Safety Data Sheet before handling product. Use of any information contained herein is provided at the reader's own risk and thus independent judgment by trained professionals must be utilized at all times. 

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