1,4-BUTYNEDIOL

diols 

2-BUTYNE-1,4-DIOL; BUT-2-YNE-1,4-DIOL; 1,4-DIHYDROXY-2-BUTYNE; 2-BUTYNEDIOL; BIS(HYDROXYMETHYL)ACETYLENE; BUTYNEDIOL; UN 2716; C4H6O2

Emergency Overview 

Color:  colorless to amber 

Change in color: Not available

Physical Form: crystals, flakes

Odor:  odorless 

Health Hazards:  harmful on contact with the skin, harmful if swallowed, skin irritation, eye irritation, tears, liver damage 

Physical Hazards:  Dust/air mixtures may ignite or explode. May decompose violently on heating. 

Short Term:  irritation 

Long Term:  no information is available 

Short Term:  irritation, liver damage 

Long Term:  irritation 

Short Term:  irritation, tearing 

Long Term:  irritation 

Short Term:  no information on significant adverse effects 

Long Term:  kidney damage, liver damage 

If adverse effects occur, remove to uncontaminated area. Give artificial respiration if not breathing. If breathing is difficult, oxygen should be administered by qualified personnel. Get immediate medical attention. 

Wash skin with soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention, if needed. Thoroughly clean and dry contaminated clothing and shoes before reuse. 

Flush eyes with plenty of water for at least 15 minutes. Then get immediate medical attention. 

If swallowed, drink plenty of water, do NOT induce vomiting. Get immediate medical attention. Induce vomiting only at the instructions of a physician. Do not give anything by mouth to unconscious or convulsive person. 

For inhalation, consider oxygen. For ingestion, consider gastric lavage, activated charcoal slurry and catharsis. 

See Section 9 for Flammability Properties 

Slight fire hazard. Dust/air mixtures may ignite or explode. 

regular dry chemical, regular foam, water Large fires: Use regular foam or flood with fine water spray. 

Move container from fire area if it can be done without risk. Fight large fires from a protected location or safe distance. Stay away from the ends of tanks. Dike for later disposal. Do not scatter spilled material with high-pressure water streams. Use extinguishing agents appropriate for surrounding fire. Avoid inhalation of material or combustion by-products. Stay upwind and keep out of low areas. 

Do not touch spilled material. Stop leak if possible without personal risk. Reduce vapors with water spray. Small spills: Absorb with sand or other non-combustible material. Collect spilled material in appropriate container for disposal. Small dry spills: Move containers away from spill to a safe area. Large spills: Dike for later disposal. Keep unnecessary people away, isolate hazard area and deny entry. Ventilate closed spaces before entering. 

Store and handle in accordance with all current regulations and standards. Store in a cool, dry place. Store in a well-ventilated area. Store in a tightly closed container. Store between 0 C and 5 C. Keep separated from incompatible substances. 

Component Exposure Limits 

Biological limit value 

Provide local exhaust or process enclosure ventilation system. Ventilation equipment should be explosion-resistant if explosive concentrations of material are present. Ensure compliance with applicable exposure limits. 

Eyes/Face Wear splash resistant safety goggles with a faceshield. Provide an emergency eye wash fountain and quick drench shower in the immediate work area. 

Wear appropriate chemical resistant clothing. 

Wear appropriate chemical resistant gloves. 

rubber/neoprene laminate 

Under conditions of frequent use or heavy exposure, respiratory protection may be needed. Respiratory protection is ranked in order from minimum to maximum. Consider warning properties before use. Any particulate respirator equipped with an N95, R95, or P95 filter (including N95, R95, and P95 filtering facepieces) except quarter-mask respirators. The following filters may also be used: N99, R99, P99, N100, R100 or P100. Any air-purifying full-facepiece respirator equipped with an N95, R95, or P95 filter. The following filters may also be used: N99, R99, P99, N100, R100 or P100. Any powered, air-purifying respirator with a high-efficiency particulate filter. Any powered, air-purifying respirator with a tight-fitting facepiece and a high-efficiency particulate filter. Any supplied-air respirator with a full facepiece that is operated in a pressure-demand or other positive-pressure mode. For Unknown Concentrations or Immediately Dangerous to Life or Health - Any supplied-air respirator with a full facepiece that is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode. Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. 

ethanol, acetone, alcohol, acidic solutions 

ether, benzene 

May decompose violently on heating. 

Avoid heat, flames, sparks and other sources of ignition. Containers may rupture or explode if exposed to heat. 

acids, bases, metal salts, oxidizing materials, 

1,4-BUTYNEDIOL: ACIDS (STRONG): Trace amounts of mercury salts may cause an explosive reaction. ALKALIES: Trace amounts may cause an explosive reaction during distillation. ALKALINE EARTH HYDROXIDES: Trace amounts may cause an explosive reaction during distillation. BASIC CATALYSTS: Absence of a solvent at room temperature or elevated temperature may cause uncontrollable decomposition. HALIDES: May explode at high temperatures. Trace amounts may cause an explosive reaction during distillation. HALIDE SALTS: Trace amounts may cause an explosive reaction during distillation. HYDROXIDES: Trace amounts may cause an explosive reaction during distillation. MERCURY SALTS: Trace amounts and high temperature may cause an explosive reaction. OXIDIZERS (STRONG): Fire and explosion hazard.

oxides of carbon 

Thermal decomposition products: oxides of carbon.

Will not polymerize. 

Component Analysis - LD50/LC50 

Component Carcinogenicity

None of this product's components are listed by ACGIH, IARC, NTP, DFG or OSHA

skin disorders and allergies 

1,4-BUTYNEDIOL May cause irritation to the respiratory tract.

1,4-BUTYNEDIOL No data available.

1,4-BUTYNEDIOL: Occupational exposure has resulted in severe irritation Application of a 40% aqueous solution at 5 g/kg for 24 hours to rat skin resulted in death for 1/2 of the rats tested within 48 hours Different stages of degeneration, including necrosis, were observed in the kidney and liver By day 14, extensive vaculation of the liver parenchyma was observed.

1,4-BUTYNEDIOL: One case of contact dermatitis has been reported in humans Animal studies indicate low sensitizing potential.

1,4-BUTYNEDIOL: Occupational exposure has resulted in severe irritation Application to rabbit eyes resulted in marked lacrimation and slightly closed lids one hour after application After 24 and 48 hours, minimal conjunctival erythema was evident.

1,4-BUTYNEDIOL No data available.

1,4-BUTYNEDIOL: Rats were administered a 10% aqueous solution in doses of 100, 150, 180, 200, 250 mg/kg Signs of toxicity and mortality over a 14 day period were observed Gross pathologies included diarrhea and congestion of internal organs, perivascular edema, bronchopneumonia, hyperemia, liver necrosis, and nephrosis After 14 days, slight lymphocytic infiltration, and mitotic cells were seen The renal cortex showed sloughing of tubular epithelium after 48 hours.

1,4-BUTYNEDIOL: In one study, rats were given a single daily dose of 1 mg/kg, 10 mg/kg, or 50 mg/kg for 28 consecutive days Three of the 8 males and 3 of the 8 females in the high dose group died After 28 days all animals were necropsied Treatment-related effects in the high dose group consisted of congestion of internal organs, pulmonary edema, depressed body weight gain in males, necrosis of the kidney and liver in both sexes, decreased red blood cell count, hematocrit value, hemoglobin concentration in females, elevated reticulocyte count and leukocyte count in both sexes, increased total serum protein content in females, elevated glucose concentration in males, higher activity of sorbitol dehydrogenase in both sexes, and hepatic and splenic changes in the survivors of the study Minor hepatic, splenic, and erythrocytic changes were also found in some females of the median dose group Histopathological evidence of hepatotoxicity and nephrotoxicity in decedents was observed.

Component Analysis - Aquatic Toxicity 

Subject to disposal regulations: U.S. EPA 40 CFR 262. Hazardous Waste Number(s): D003. Dispose in accordance with all applicable regulations. 

Component Waste Numbers 

ADR Tunnel Code Restrictions 

Component Marine Pollutants (IMDG) 

SARA Section 311/312 (40 CFR 370 Subparts B and C) 

Not listed under California Proposition 65 

Germany Water Classification 

The listed component(s) of this material have been checked for country-specific published classifications according to the Globally Harmonized System of Classification and Labeling (GHS). The results of the queries are displayed below. Please see the individual country listings, as additional interpretations or reference information may be available. For a reference list of H- or P-statements, please visit ChemADVISOR’s website at http://www.chemadvisor.com/product-resources/26-pure-substance-and-mixture-databases/247-ghs-hazard-and-physical-statements 

Australia GHS Classifications 

Australia GHS Labeling Information 

European Union GHS Classifications 

European Union GHS Labeling Information 

Indonesia GHS Classifications 

Japan GHS Classifications 

Japan GHS Labeling Information 

Korea GHS Classifications 

Korea GHS Labeling Information 

New Zealand GHS Classifications 

New Zealand GHS Labeling Information 

South Africa GHS Classifications 

Taiwan GHS Classifications 

Taiwan GHS Labeling Information 

No classification assigned. 

ACGIH - American Conference of Governmental Industrial Hygienists; ADR - European Road Transport; AU - Australia; BOD - Biochemical Oxygen Demand; C - Celsius; CA - Canada; CAS - Chemical Abstracts Service; CERCLA - Comprehensive Environmental Response, Compensation, and Liability Act; CN - China; CPR - Controlled Products Regulations; DFG - Deutsche Forschungsgemeinschaft; DOT - Department of Transportation; DSL - Domestic Substances List; EEC - European Economic Community; EINECS - European Inventory of Existing Commercial Chemical Substances; EPA - Environmental Protection Agency; EU - European Union; F - Fahrenheit; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; ICAO - International Civil Aviation Organization; IDL - Ingredient Disclosure List; IDLH - Immediately Dangerous to Life and Health; IMDG - International Maritime Dangerous Goods; JP - Japan; Kow - Octanol/water partition coefficient; KR - Korea; LEL - Lower Explosive Limit; LOLI - List Of LIsts™ - ChemADVISOR’s Regulatory Database; MAK - Maximum Concentration Value in the Workplace; MEL - Maximum Exposure Limits; NFPA - National Fire Protection Agency; NIOSH - National Institute for Occupational Safety and Health; NJTSR - New Jersey Trade Secret Registry; NTP - National Toxicology Program; NZ - New Zealand; OSHA - Occupational Safety and Health Administration; PH - Philippines; RCRA - Resource Conservation and Recovery Act; RID - European Rail Transport; RTECS - Registry of Toxic Effects of Chemical Substances®; SARA - Superfund Amendments and Reauthorization Act; STEL - Short-term Exposure Limit; TDG - Transportation of Dangerous Goods; TSCA - Toxic Substances Control Act; TWA - Time Weighted Average; UEL - Upper Explosive Limit; US - United States 

Reasonable care has been taken in the preparation of this information; however, the manufacturer makes no warranty whatsoever including the warranty of merchantability, expressed or implied, with respect to this information. The manufacturer makes no representations and assumes no liability for any direct, incidental, consequential, or other such damages resulting from its use or misuse. 

Supplier gives no warranty whatsoever, including the warranties of merchantability or of fitness for a particular purpose. Any product purchased is sold on the assumption the purchaser shall determine the quality and suitability of the product. Supplier expressly disclaims any and all liability for incidental, consequential or any other damages arising out of the use or misuse of this product. No information provided shall be deemed to be a recommendation to use any product in conflict with any existing patent rights. THIS SDS IS TO BE UTILIZED SOLELY AS A REFERENCE DOCUMENT AND IT IS NOT TO BE USED TO SATISFY THE DISTRIBUTION REQUIREMENTS OF OSHA'S HAZARD COMMUNICATION STANDARD (HCS) NOR CANADA'S CONTROLLED PRODUCT REGULATION (CPR). Read the Safety Data Sheet before handling product. Use of any information contained herein is provided at the reader's own risk and thus independent judgment by trained professionals must be utilized at all times. 

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