1,2-DIBROMO-3-CHLOROPROPANE

halogenated, aliphatic 

1-CHLORO-2,3-DIBROMOPROPANE; 3-CHLORO-1,2-DIBROMOPROPANE; DIBROMOCHLOROPROPANE; 2-DIBROMO-3-CHLOROPROPANE; DBCP; RCRA U066; UN 2872; C3H5Br2Cl

Emergency Overview 

Color:  colorless to amber 

Change in color: Not available

Physical Form: liquid

Odor:  irritating odor 

Health Hazards:  potentially fatal if inhaled, harmful if swallowed, respiratory tract irritation, skin irritation, central nervous system depression, cancer 

Physical Hazards:  Flash back hazard. Combustible liquid and vapor. 

Short Term:  potentially fatal if inhaled, irritation, nausea, headache, drowsiness, dizziness, loss of coordination, lung congestion 

Long Term:  impaired fertility 

Short Term:  irritation 

Long Term:  irritation 

Short Term:  irritation 

Long Term:  irritation, eye damage 

Short Term:  weight loss, headache, drowsiness, dizziness, loss of coordination 

Long Term:  cancer 

If adverse effects occur, remove to uncontaminated area. Give artificial respiration if not breathing. If breathing is difficult, oxygen should be administered by qualified personnel. Get immediate medical attention. 

Wash skin with soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention, if needed. Thoroughly clean and dry contaminated clothing and shoes before reuse. 

Flush eyes with plenty of water for at least 15 minutes. Then get immediate medical attention. 

If swallowed, drink plenty of water, do NOT induce vomiting. Get immediate medical attention. Induce vomiting only at the instructions of a physician. Do not give anything by mouth to unconscious or convulsive person. 

For inhalation, consider oxygen. For ingestion, consider gastric lavage. 

See Section 9 for Flammability Properties 

Moderate fire hazard. Vapor/air mixtures are explosive above flash point. The vapor is heavier than air. Vapors or gases may ignite at distant ignition sources and flash back. 

regular dry chemical, carbon dioxide, water, regular foam Large fires: Use regular foam or flood with fine water spray. 

Do not touch spilled material. Use extinguishing agents appropriate for surrounding fire. Flood with fine water spray. Cool containers with water spray until well after the fire is out. Reduce vapors with water spray. Avoid inhalation of material or combustion by-products. Stay upwind and keep out of low areas. 

oxides of carbon, halogenated compounds 

Subject to California Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). Keep out of water supplies and sewers. 

Do not touch spilled material. Stop leak if possible without personal risk. Small spills: Absorb with sand or other non-combustible material. Collect spilled material in appropriate container for disposal. Large spills: Dike for later disposal. Keep unnecessary people away, isolate hazard area and deny entry. Ventilate closed spaces before entering. Notify Local Emergency Planning Committee and State Emergency Response Commission for release greater than or equal to RQ (U.S. SARA Section 304). If release occurs in the U.S. and is reportable under CERCLA Section 103, notify the National Response Center at (800)424-8802 (USA) or (202)426-2675 (USA). 

Store and handle in accordance with all current regulations and standards. Store in a tightly closed container. Store at room temperature. Store in a well-ventilated area. Subject to storage regulations: U.S. OSHA 29 CFR 1910.106. Grounding and bonding required. Keep separated from incompatible substances. 

Component Exposure Limits 

Biological limit value 

Provide local exhaust or process enclosure ventilation system. Ensure compliance with applicable exposure limits. 

Eyes/Face Wear splash resistant safety goggles with a faceshield. Provide an emergency eye wash fountain and quick drench shower in the immediate work area. Contact lenses should not be worn. 

Wear appropriate chemical resistant clothing. 

Wear appropriate chemical resistant gloves. OSHA REGULATED SUBSTANCES: U.S. OSHA 29 CFR 1910.1044. 

The following respirators and maximum use concentrations are drawn from NIOSH and/or OSHA. OSHA Standard: Respirator selection should comply with 29 CFR 1910.134, 29 CFR 1910.1044, and the final rule published in the Federal Register on August 24, 2006. NIOSH Recommendations: At any detectable concentration - Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Any supplied-air respirator with a full facepiece that is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode. Escape - Any air-purifying full-facepiece respirator (gas mask) with a chin-style, front-mounted or back-mounted organic vapor canister having an N100, R100, or P100 filter. Any appropriate escape-type, self-contained breathing apparatus. 

halogenated solvents, acetone, methanol, dichloropropane, dimethyl sulfoxide, ethanol, ether, benzene, heptane, oils, isopropanol, aliphatic & aromatic solvents 

Stable at normal temperatures and pressure. 

Avoid heat, flames, sparks and other sources of ignition. 

bases, oxidizing materials, metals, 

1,2-DIBROMO-3-CHLOROPROPANE: ALKALI: May cause hydrolysis to 2-bromoallyl alcohol. ALUMINIUM + ALUMINUM ALLOYS: May be corroded. COPPER ALLOYS + WATER: May be corroded. MAGNESIUM + MAGNESIUM ALLOYS: May be corroded. OXIDIZERS (STRONG): Fire and explosion hazard. RUBBER + COATINGS: Some forms may be attacked. STEEL ALLOYS + WATER: May be corroded. TIN + TIN ALLOYS: May be corroded.

oxides of carbon, halogenated compounds 

Thermal decomposition products: brominated compounds, chlorinated compounds.

Will not polymerize. 

Component Analysis - LD50/LC50 

Component Carcinogenicity

1,2-Dibromo-3-chloropropane produced squamous-cell carcinomas of the forestomach in rats and mice and carcinomas of the mammary gland in female rats by chronic oral ingestion Chronic inhalation studies in rats and mice reported an increased incidence of lung and nasal cavity tumors in mice, tumors of the nasal cavity and tongue in both sexes of rats, and cortical adenomas in the adrenal gland of female rats. 

genitourinary disorders, kidney disorders, liver disorders, skin disorders and allergies, 

Stimulants such as epinephrine may induce ventricular fibrillation. 

This chemical was reported to have induced sterility among exposed male workers. 

1,2-DIBROMO-3-CHLOROPROPANE: May cause respiratory irritation, nausea, pulmonary congestion or edema and central nervous system depression with apathy, sluggishness, and ataxia Vapor concentrations of 60 ppm produced irritation of the respiratory tract, nausea, chills, central nervous depression with apathy and ataxia, and kidney damage in rats.

1,2-DIBROMO-3-CHLOROPROPANE: Male workers employed in the production and formulation of 1,2 dibromo-3-chloropropane have experienced a decreased spermatogensis, decreased testicular size and increased follicle stimulating hormone (fsh) levels It is not clearly established whether this condition is completely reversible in all cases once exposure is discontinued However some individuals have fathered normal children after recovery of the sperm count Repeated exposures of rats to 12 ppm produced severe atrophy and degeneration of testes, degenerative changes of the seminiferous tubules, reduction in sperm count, and abnormal development of sperm cells; mild damage to the liver and kidneys was also reported Rabbits exposed to 1 ppm for 14 weeks had a 50% reduction in testicular size and decreased spermatogenesis in the remaining tubules; 10 ppm produced almost complete atrophy of the testes in rabbits by the 8th week of exposure Two female monkeys repeated exposed to 12 ppm developed severe leukopenias and anemias Chronic inhalation studies of rats and mice reported an increased incidence of lung and nasal cavity tumors in mice, nasal cavity tumors and tumors of the tongue in both sexes of rats, and cortical adenomas in the adrenal gland of female rats.

1,2-DIBROMO-3-CHLOROPROPANE: May cause irritation Application of 0.5 ml to the shaven backs of 4 rabbits produced slight erythema in abraded areas of skin and no signs of irritation in intact skin A lethal dose in rabbits by dermal absorption was 1400 mg/kg.

1,2-DIBROMO-3-CHLOROPROPANE: Repeated exposure may cause erythema or inflammation and dermatitis Repeated application to the skin of a rabbit resulted in a slight crustiness of the epidermis and extensive necrosis of the dermis and subcutanous tissue As evaluated by RTECS, repeated application to the skins of mice resulted in a statistically significant increase in the incidence of carcinogenic tumors of skin and appendages and the respiratory system.

1,2-DIBROMO-3-CHLOROPROPANE: The liquid applied to rabbit eyes in undiluted form or as a 1% solution in propylene glycol caused slight irritation and pain of the conjunctivae and iris that disappeared after 1-2 days Exposure to concentration as high as 400 ppm produced clouding of the cornea or lens in rats.

1,2-DIBROMO-3-CHLOROPROPANE: Chronic exposure to vapors may lead to permanent eye damage Repeated exposures to 12 ppm in laboratory animals caused corneal damage.

1,2-DIBROMO-3-CHLOROPROPANE: A lethal dose in rats was 170 mg/kg A dose of 100 mg/kg produced inhibition of the central nervous system, prolonged weight loss, and decreased spermatogensis in rats In female rats, a dose of 100 mg/kg prolonged the estrus cycle A single dose of 126 mg/kg given to male rats resulted in kidney degeneration and depressed body weight, which took a long time for recovery.

1,2-DIBROMO-3-CHLOROPROPANE: Repeated ingestion by rats of daily doses of 0.5 mg/kg resulted in pronounced necrotic action on the parenchymatous organs (i.e., Liver, kidney, spleen) and on the testicles of rats Daily doses of 10 mg/kg administered to rats for 4 to 5 months decreased the concentration of spermatozoa in the semen and the duration of motility of the spermatozoa in male rats; in female rats, the estrus cycle was prolonged with both estrus and diestrus becoming longer Repeated oral doses of this material in mice and rats produced squamous-cell carcinomas of the forestomach in animals of both species and adenocarcinomas of the mammary gland in female rats.

Component Analysis - Aquatic Toxicity 

Dispose in accordance with all applicable regulations. Subject to disposal regulations: U.S. EPA 40 CFR 262. Hazardous Waste Number(s): U066. 

Component Waste Numbers 

Component Marine Pollutants (IMDG) 

SARA Section 311/312 (40 CFR 370 Subparts B and C) 

The following statement(s) are provided under the California Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65): 

Canadian WHMIS Ingredient Disclosure List (IDL) 

REACH List of Substances Subject to Restriction (Annex XVII) - Reg. (EU) No. 1907/2006 

The listed component(s) of this material have been checked for country-specific published classifications according to the Globally Harmonized System of Classification and Labeling (GHS). The results of the queries are displayed below. Please see the individual country listings, as additional interpretations or reference information may be available. For a reference list of H- or P-statements, please visit ChemADVISOR’s website at http://www.chemadvisor.com/product-resources/26-pure-substance-and-mixture-databases/247-ghs-hazard-and-physical-statements 

Australia GHS Classifications 

Australia GHS Labeling Information 

European Union GHS Classifications 

European Union GHS Labeling Information 

Indonesia GHS Classifications 

Japan GHS Classifications 

Japan GHS Labeling Information 

Korea GHS Classifications 

Korea GHS Labeling Information 

New Zealand GHS Classifications 

South Africa GHS Classifications 

Taiwan GHS Classifications 

Taiwan GHS Labeling Information 

No classification assigned. 

ACGIH - American Conference of Governmental Industrial Hygienists; ADR - European Road Transport; AU - Australia; BOD - Biochemical Oxygen Demand; C - Celsius; CA - Canada; CAS - Chemical Abstracts Service; CERCLA - Comprehensive Environmental Response, Compensation, and Liability Act; CN - China; CPR - Controlled Products Regulations; DFG - Deutsche Forschungsgemeinschaft; DOT - Department of Transportation; DSL - Domestic Substances List; EEC - European Economic Community; EINECS - European Inventory of Existing Commercial Chemical Substances; EPA - Environmental Protection Agency; EU - European Union; F - Fahrenheit; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; ICAO - International Civil Aviation Organization; IDL - Ingredient Disclosure List; IDLH - Immediately Dangerous to Life and Health; IMDG - International Maritime Dangerous Goods; JP - Japan; Kow - Octanol/water partition coefficient; KR - Korea; LEL - Lower Explosive Limit; LOLI - List Of LIsts™ - ChemADVISOR’s Regulatory Database; MAK - Maximum Concentration Value in the Workplace; MEL - Maximum Exposure Limits; NFPA - National Fire Protection Agency; NIOSH - National Institute for Occupational Safety and Health; NJTSR - New Jersey Trade Secret Registry; NTP - National Toxicology Program; NZ - New Zealand; OSHA - Occupational Safety and Health Administration; PH - Philippines; RCRA - Resource Conservation and Recovery Act; RID - European Rail Transport; RTECS - Registry of Toxic Effects of Chemical Substances®; SARA - Superfund Amendments and Reauthorization Act; STEL - Short-term Exposure Limit; TDG - Transportation of Dangerous Goods; TSCA - Toxic Substances Control Act; TWA - Time Weighted Average; UEL - Upper Explosive Limit; US - United States 

Reasonable care has been taken in the preparation of this information; however, the manufacturer makes no warranty whatsoever including the warranty of merchantability, expressed or implied, with respect to this information. The manufacturer makes no representations and assumes no liability for any direct, incidental, consequential, or other such damages resulting from its use or misuse. 

Supplier gives no warranty whatsoever, including the warranties of merchantability or of fitness for a particular purpose. Any product purchased is sold on the assumption the purchaser shall determine the quality and suitability of the product. Supplier expressly disclaims any and all liability for incidental, consequential or any other damages arising out of the use or misuse of this product. No information provided shall be deemed to be a recommendation to use any product in conflict with any existing patent rights. THIS SDS IS TO BE UTILIZED SOLELY AS A REFERENCE DOCUMENT AND IT IS NOT TO BE USED TO SATISFY THE DISTRIBUTION REQUIREMENTS OF OSHA'S HAZARD COMMUNICATION STANDARD (HCS) NOR CANADA'S CONTROLLED PRODUCT REGULATION (CPR). Read the Safety Data Sheet before handling product. Use of any information contained herein is provided at the reader's own risk and thus independent judgment by trained professionals must be utilized at all times. 

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