Safety Data Sheet: Material Name: VERAPAMIL HYDROCHLORIDE SDS ID: ohs24874 Issue Date: 2016-06-23 Revision: 2.07

                

VERAPAMIL HYDROCHLORIDE

ChemADVISOR, Inc. Stone Quarry Crossing 811 Camp Horne Road, Suite 220 Pittsburgh, PA 15237 E-mail: info@chemadvisor.com MSDS is for reference use only; please contact manufacturer for emergency response information, routine product inquiries and orders.

bicyclic, amines 



BENZENEACETONITRILE, ALPHA-(3-((2-(3,4-DIMETHOXYPHENYL)ETHYL) METHYLAMINO)PROPYL)-3,4-DIMETHOXY-ALPHA-(1-METHYLETHYL)-, MONOHYDROCHLORIDE; ALPHA-(3-((2-(3,4-DIMETHOXYPHENYL)ETHYL)METHYLAMINO)PROPYL)-3,4- DIMETHOXY-ALPHA-(1-METHYLETHYL)-BENZENEACETONITRILE, MONOHYDROCHLORIDE; VALERONITRILE, 5-((3,4-DIMETHOXYPHENETHYL)METHYLAMINO)-2-(3,4- DIMETHOXYPHENYL)-2-ISOPROPYL-,MONOHYDROCHLORIDE; 5-((3,4-DIMETHOXYPHENETHYL)METHYLAMINO)-2-(3,4-DIMETHOXYPHENYL)-2- ISOPROPYL-VALERONITRILE, MONOHYDROCHLORIDE; VALERNITRILE, 5-((3,4-DIMETHOXYPHENETHYL)METHYLAMINO)-2-(3,4- DIMETHOXYPHENYL)-2-ISOPROPYL-, HYDROCHLORIDE; 5-((3,4,DIMETHOXYPHENETHYL)METHYLAMINO)-2-(3,4-DIMETHOXYPHENYL)-2- ISOPROPYL VALERONITRILE, HYDROCHLORIDE; ISOPTIN; VERELAN; C27H39CLN2O4

Emergency Overview 

Color:  white 

Change in color: light-sensitive

Physical Form: crystals

Odor:  odorless 

Health Hazards:  harmful if swallowed 

Physical Hazards:  Dust/air mixtures may ignite or explode. 

Short Term:  no information is available 

Long Term:  no information is available 

Short Term:  no information is available 

Long Term:  no information is available 

Short Term:  no information on significant adverse effects 

Long Term:  no information on significant adverse effects 

Short Term:  nausea, vomiting, irregular heartbeat, headache, dizziness, pin-point pupils, convulsions, coma 

Long Term:  rash, ringing in the ears, difficulty breathing, blurred vision, lung congestion, liver damage 

CAS EC No Registration No	Component Name Synonyms	1272/2008 (CLP)	Percent
152-11-4 205-800-5 --	VERAPAMIL HYDROCHLORIDE	--	100.0

If adverse effects occur, remove to uncontaminated area. Give artificial respiration if not breathing. Get immediate medical attention. 



Wash skin with soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention, if needed. Thoroughly clean and dry contaminated clothing and shoes before reuse. 



Flush eyes with plenty of water for at least 15 minutes. Then get immediate medical attention. 



Contact local poison control center or physician immediately. Never make an unconscious person vomit or drink fluids. When vomiting occurs, keep head lower than hips to help prevent aspiration. If person is unconscious, turn head to side. Get medical attention immediately. 



For ingestion, consider gastric lavage and activated charcoal slurry. 



calcium chloride, intravenous; calcium gluconate, intravenous. 









See Section 9 for Flammability Properties 



Slight fire hazard. Dust/air mixtures may ignite or explode. 



regular dry chemical, carbon dioxide, water, regular foam Large fires: Use regular foam or flood with fine water spray. 



Move container from fire area if it can be done without risk. Use extinguishing agents appropriate for surrounding fire. Avoid inhalation of material or combustion by-products. Stay upwind and keep out of low areas. 









Do not touch spilled material. Stop leak if possible without personal risk. Small spills: Absorb with sand or other non-combustible material. Collect with absorbent into suitable container. Small dry spills: Collect spilled material in appropriate container for disposal. Move containers away from spill to a safe area. Large spills: Dike for later disposal. Keep unnecessary people away, isolate hazard area and deny entry. 









Store and handle in accordance with all current regulations and standards. Store in a cool, dry place. Keep in the dark. Keep separated from incompatible substances. 

Component Exposure Limits 

Biological limit value 



Provide local exhaust or process enclosure ventilation system. Ventilation equipment should be explosion-resistant if explosive concentrations of material are present. Ensure compliance with applicable exposure limits. 



Eyes/Face Wear splash resistant safety goggles. Provide an emergency eye wash fountain and quick drench shower in the immediate work area. 



Wear appropriate chemical resistant clothing. 



Wear appropriate chemical resistant gloves. 



Under conditions of frequent use or heavy exposure, respiratory protection may be needed. Respiratory protection is ranked in order from minimum to maximum. Consider warning properties before use. Any particulate respirator equipped with an N95, R95, or P95 filter (including N95, R95, and P95 filtering facepieces) except quarter-mask respirators. The following filters may also be used: N99, R99, P99, N100, R100 or P100. Any air-purifying full-facepiece respirator equipped with an N95, R95, or P95 filter. The following filters may also be used: N99, R99, P99, N100, R100 or P100. Any powered, air-purifying respirator with a high-efficiency particulate filter. Any powered, air-purifying respirator with a tight-fitting facepiece and a high-efficiency particulate filter. Any supplied-air respirator with a full facepiece that is operated in a pressure-demand or other positive-pressure mode. For Unknown Concentrations or Immediately Dangerous to Life or Health - Any supplied-air respirator with a full facepiece that is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode. Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. 

Appearance	Not available	Physical State	Solid
Odor	odorless	Color	white
Odor Threshold	Not available	pH	5.25
Melting Point	Not available	Boiling Point	Not available
Freezing point	Not available	Evaporation Rate	Not available
Boiling Point Range	Not available	Flammability (solid, gas)	Not available
Autoignition	Not available	Flash Point	Not available
Lower Explosive Limit	Not available	Decomposition	139 - 144 °C
Upper Explosive Limit	Not available	Vapor Pressure	Not available
Vapor Density (air=1)	Not available	Specific Gravity (water=1)	Not available
Water Solubility	7 % (21 °C)	Partition coefficient: n-octanol/water	Not available
Viscosity	Not available	Solubility (Other)	Not available
Change in color	light-sensitive	Density	Not available
pH Solution	0.1 %	Physical Form	crystals
Taste	bitter taste	Molecular Formula	C27-H38-N2-O4.H-CL
Molecular Weight	491.07

ethanol, isopropanol, acetone, dichloromethane, methanol, dimethylformamide 



propylene glycols 



chloroform, isopropanol, ethyl acetate, hexane 













Stable at normal temperatures and pressure. 



Avoid heat, flames, sparks and other sources of ignition. Avoid generating dust. Keep out of water supplies and sewers. 



bases, oxidizing materials, 

VERAPAMIL HYDROCHLORIDE: ALKALIS (STRONG): Incompatible. OXIDIZERS (STRONG): Fire and explosion hazard.

oxides of nitrogen, carbon, halogenated compounds 

Thermal decomposition products: oxides of nitrogen, carbon, chlorides.

Will not polymerize. 

Component Analysis - LD50/LC50 

Component Carcinogenicity

None of this product's components are listed by ACGIH, IARC, NTP, DFG or OSHA

liver and/or kidney disorders, heart or cardiovascular disorders, nervous system disorders, 



May cross the placenta May be excreted in breast milk Interactions with drugs may occur. 



VERAPAMIL HYDROCHLORIDE No data available.



VERAPAMIL HYDROCHLORIDE No data available.



VERAPAMIL HYDROCHLORIDE No data available.



VERAPAMIL HYDROCHLORIDE No data available.



VERAPAMIL HYDROCHLORIDE A transitory rise of intraocular pressure was caused by 5% eyedrops in rabbits.



VERAPAMIL HYDROCHLORIDE Chronic studies in dogs reported changes in the lens of the eye at 30 mg/kg/day and cataract formation at 62.5 mg/kg/day.



VERAPAMIL HYDROCHLORIDE: Ingestion of 3.2 grams by humans caused nodal bradycardia, a v dissociation, intraventricular conduction abnormalities, hypotension, lethargy, and miosis Other manifestations of overdosage may include nausea, vomiting, lightheadedness, headache, apnea, seizures, and coma Hyperglycemia and metabolic acidosis have occurred The lethal dose reported in rats was 108 mg/kg.



VERAPAMIL HYDROCHLORIDE: Therapeutic use may most frequently cause constipation, dizziness, nausea, hypotension, headache, edema, congestive heart failure, pulmonary edema, fatigue, dyspnea, bradycardia, av block, rash, and flushing Low incidences of cardiovascular, digestive, nervous, and urogenital system effects and blurred vision and bruising have occurred No cause and effect relationship has been established Other reported effects include tinnitus, rhinitis, liver damage, and galactorrhea Chronic doses caused cataracts in some groups of dogs but not in others, nor in rats, rabbits or baboons Development of cataracts due to verapamil has not been reported in man.

Component Analysis - Aquatic Toxicity 

Dispose in accordance with all applicable regulations. 

Component Waste Numbers 

Component Marine Pollutants (IMDG) 

SARA Section 311/312 (40 CFR 370 Subparts B and C) 

Not listed under California Proposition 65 

The listed component(s) of this material have been checked for country-specific published classifications according to the Globally Harmonized System of Classification and Labeling (GHS). The results of the queries are displayed below. Please see the individual country listings, as additional interpretations or reference information may be available. For a reference list of H- or P-statements, please visit ChemADVISOR’s website at http://www.chemadvisor.com/product-resources/26-pure-substance-and-mixture-databases/247-ghs-hazard-and-physical-statements 

Australia GHS Classifications 

European Union GHS Classifications 

Indonesia GHS Classifications 

Japan GHS Classifications 

Korea GHS Classifications 

New Zealand GHS Classifications 

New Zealand GHS Labeling Information 

South Africa GHS Classifications 

Taiwan GHS Classifications 

No classification assigned. 









ACGIH - American Conference of Governmental Industrial Hygienists; ADR - European Road Transport; AU - Australia; BOD - Biochemical Oxygen Demand; C - Celsius; CA - Canada; CAS - Chemical Abstracts Service; CERCLA - Comprehensive Environmental Response, Compensation, and Liability Act; CN - China; CPR - Controlled Products Regulations; DFG - Deutsche Forschungsgemeinschaft; DOT - Department of Transportation; DSL - Domestic Substances List; EEC - European Economic Community; EINECS - European Inventory of Existing Commercial Chemical Substances; EPA - Environmental Protection Agency; EU - European Union; F - Fahrenheit; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; ICAO - International Civil Aviation Organization; IDL - Ingredient Disclosure List; IDLH - Immediately Dangerous to Life and Health; IMDG - International Maritime Dangerous Goods; JP - Japan; Kow - Octanol/water partition coefficient; KR - Korea; LEL - Lower Explosive Limit; LOLI - List Of LIsts™ - ChemADVISOR’s Regulatory Database; MAK - Maximum Concentration Value in the Workplace; MEL - Maximum Exposure Limits; NFPA - National Fire Protection Agency; NIOSH - National Institute for Occupational Safety and Health; NJTSR - New Jersey Trade Secret Registry; NTP - National Toxicology Program; NZ - New Zealand; OSHA - Occupational Safety and Health Administration; PH - Philippines; RCRA - Resource Conservation and Recovery Act; RID - European Rail Transport; RTECS - Registry of Toxic Effects of Chemical Substances®; SARA - Superfund Amendments and Reauthorization Act; STEL - Short-term Exposure Limit; TDG - Transportation of Dangerous Goods; TSCA - Toxic Substances Control Act; TWA - Time Weighted Average; UEL - Upper Explosive Limit; US - United States 



Reasonable care has been taken in the preparation of this information; however, the manufacturer makes no warranty whatsoever including the warranty of merchantability, expressed or implied, with respect to this information. The manufacturer makes no representations and assumes no liability for any direct, incidental, consequential, or other such damages resulting from its use or misuse.  Supplier gives no warranty whatsoever, including the warranties of merchantability or of fitness for a particular purpose. Any product purchased is sold on the assumption the purchaser shall determine the quality and suitability of the product. Supplier expressly disclaims any and all liability for incidental, consequential or any other damages arising out of the use or misuse of this product. No information provided shall be deemed to be a recommendation to use any product in conflict with any existing patent rights. THIS SDS IS TO BE UTILIZED SOLELY AS A REFERENCE DOCUMENT AND IT IS NOT TO BE USED TO SATISFY THE DISTRIBUTION REQUIREMENTS OF OSHA'S HAZARD COMMUNICATION STANDARD (HCS) NOR CANADA'S CONTROLLED PRODUCT REGULATION (CPR). Read the Safety Data Sheet before handling product. Use of any information contained herein is provided at the reader's own risk and thus independent judgment by trained professionals must be utilized at all times. 







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