COBEHN SOLVENT H

INV# 05404

Emergency Overview 

Color:  colorless 

Change in color: Not available

Physical Form: liquid

Odor:  sweet odor 

Health Hazards:  respiratory tract irritation, skin irritation, eye irritation, liver damage, central nervous system depression, difficulty breathing, nerve damage, suspect cancer hazard (in animals) 

Physical Hazards:  May explode. Flammable liquid and vapor. Vapor may cause flash fire. 

Short Term:  irritation, cough, changes in blood pressure, ringing in the ears, nausea, vomiting, diarrhea, constipation, stomach pain, weight loss, chest pain, difficulty breathing, irregular heartbeat, headache, drowsiness, dizziness, disorientation, hallucinations, tingling sensation, pain in extremities, tremors, loss of coordination, lung congestion, internal bleeding, blood disorders, heart disorders, kidney damage, nerve damage, unconsciousness, coma 

Long Term:  irritation, sensitivity to light, changes in blood pressure, nausea, vomiting, diarrhea, stomach pain, difficulty breathing, irregular heartbeat, headache, drowsiness, fatigue, dizziness, disorientation, pain in extremities, tremors, loss of coordination, visual disturbances, dilated pupils or pin-point pupils, blindness, bluish skin color, lung congestion, heart damage, kidney damage, liver damage, nerve damage, reproductive effects, effects on the brain, convulsions, unconsciousness, coma, cancer 

Short Term:  irritation, absorption may occur, changes in blood pressure, nausea, vomiting, irregular heartbeat, headache, drowsiness, dizziness, loss of coordination, blood disorders 

Long Term:  irritation, skin disorders, headache, drowsiness, dizziness, loss of coordination, blood disorders, nerve damage 

Short Term:  irritation, eye damage 

Long Term:  irritation, eye damage 

Short Term:  irritation, sensitivity to light, changes in body temperature, changes in blood pressure, nausea, vomiting, diarrhea, stomach pain, difficulty breathing, irregular heartbeat, headache, drowsiness, dizziness, disorientation, difficulty speaking, hallucinations, mood swings, pain in extremities, tremors, loss of coordination, visual disturbances, dilated pupils, dilated pupils or pin-point pupils, blindness, bluish skin color, lung congestion, internal bleeding, heart damage, kidney damage, liver damage, nerve damage, effects on the brain, convulsions, unconsciousness, coma 

Long Term:  changes in blood pressure, diarrhea, loss of appetite, weight loss, irregular heartbeat, headache, drowsiness, dizziness, disorientation, pain in extremities, tremors, loss of coordination, visual disturbances, blindness, bluish skin color, blood disorders, heart damage, kidney damage, liver damage, nerve damage, reproductive effects, birth defects, brain damage 

If adverse effects occur, remove to uncontaminated area. Give artificial respiration if not breathing. Get immediate medical attention. 

Wash skin with soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention, if needed. Thoroughly clean and dry contaminated clothing and shoes before reuse. 

Flush eyes with plenty of water for at least 15 minutes. Then get immediate medical attention. 

Contact local poison control center or physician immediately. Never make an unconscious person vomit or drink fluids. When vomiting occurs, keep head lower than hips to help prevent aspiration. If person is unconscious, turn head to side. Get medical attention immediately. 

For ingestion, consider gastric lavage. 

See Section 9 for Flammability Properties 

Severe fire hazard. The vapor is heavier than air. Vapors or gases may ignite at distant ignition sources and flash back. Vapor/air mixtures are explosive. Moderate explosion hazard. Vapor/air mixtures are explosive above flash point. 

alcohol-resistant foam, carbon dioxide, regular dry chemical, water 

Large fires: Use alcohol-resistant foam or flood with fine water spray. 

Move container from fire area if it can be done without risk. Dike for later disposal. Do not scatter spilled material with high-pressure water streams. Cool containers with water spray until well after the fire is out. Stay away from the ends of tanks. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tanks due to fire. For tank, rail car or tank truck, evacuation radius: 800 meters (1/2 mile). Do not attempt to extinguish fire unless flow of material can be stopped first. Flood with fine water spray. Do not scatter spilled material with high-pressure water streams. Cool containers with water spray until well after the fire is out. Apply water from a protected location or from a safe distance. Avoid inhalation of material or combustion by-products. Stay upwind and keep out of low areas. 

Subject to California Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). Keep out of water supplies and sewers. 

Avoid heat, flames, sparks and other sources of ignition. Do not touch spilled material. Stop leak if possible without personal risk. Reduce vapors with water spray. Small spills: Absorb with sand or other non-combustible material. Collect spilled material in appropriate container for disposal. Large spills: Dike for later disposal. Remove sources of ignition. Keep unnecessary people away, isolate hazard area and deny entry. Notify Local Emergency Planning Committee and State Emergency Response Commission for release greater than or equal to RQ (U.S. SARA Section 304). If release occurs in the U.S. and is reportable under CERCLA Section 103, notify the National Response Center at (800)424-8802 (USA) or (202)426-2675 (USA). 

Store and handle in accordance with all current regulations and standards. Subject to storage regulations: U.S. OSHA 29 CFR 1910.106. Grounding and bonding required. Keep separated from incompatible substances. 

Component Exposure Limits 

Biological limit value 

Provide local exhaust or process enclosure ventilation system. Ventilation equipment should be explosion-resistant if explosive concentrations of material are present. Ensure compliance with applicable exposure limits. 

Eyes/Face Wear splash resistant safety goggles. Provide an emergency eye wash fountain and quick drench shower in the immediate work area. 

Wear appropriate chemical resistant clothing. Remove any chemical soaked clothing immediately. 

Wear appropriate chemical resistant gloves. 

Under conditions of frequent use or heavy exposure, respiratory protection may be needed. Respiratory protection is ranked in order from minimum to maximum. Consider warning properties before use. Any supplied-air respirator with a full facepiece that is operated in a pressure-demand or other positive-pressure mode. Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. For Unknown Concentrations or Immediately Dangerous to Life or Health - Any supplied-air respirator with a full facepiece that is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode. Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. 

Stable at normal temperatures and pressure. 

metals, combustible materials, halo carbons, oxidizing materials, halogens, metal carbide, bases, acids, metal salts, peroxides, metal oxides, amines, reducing agents 

1,1,2-TRICHLORO-1,2,2-TRIFLUOROETHANE ALKALI METALS: Violent reaction possible. ALUMINUM (POWDERED): Forms shock-sensitive mixture. BARIUM (POWDERED): Forms explosive mixture. BERYLLIUM: Violent reaction possible. CALCIUM: Violent reaction possible. LITHIUM (POWDERED): Forms explosive mixture. MAGNESIUM: Violent reaction possible. MAGNESIUM ALLOY: Decomposition possible. METALS: Highly reactive. OXIDIZERS (STRONG): Fire and explosion hazard. PLASTICS, RUBBER, COATINGS: May be attacked. POTASSIUM: Forms ignitable compound. SAMARIUM: Explodes on friction. SODIUM: Forms ignitable compound. SODIUM-POTASSIUM ALLOY: Violent explosion. TITANIUM (POWDERED): Forms shock-sensitive mixture. ZINC: Violent reaction possible. ETHYL ALCOHOL (ETHANOL) ACETIC ANHYDRIDE AND SODIUM HYDROGEN SULFATE: Possible explosion. ACETYL CHLORIDE: Violent reaction. ACETYL BROMIDE: Violent reaction. ALKALI METALS: Liberates flammable hydrogen gas. ALUMINUM SESQUIBROMIDE ETHYLATE: Explosion. AMMONIUM HYDROXIDE AND SILVER (I) OXIDE: Formation of explosive silver nitride. BARIUM PERCHLORATE: Formation of explosive compound. BROMINE PENTAFLUORIDE: Ignition and explosions are possible. CALCIUM HYPOCHLORITE: Possible explosion. CHLORINE TRIOXIDE: Violent reaction. CHLORYL PERCHLORATE: Possible ignition. CHROMIC ANHYDRIDE: Ignition. CHROMIUM TRIOXIDE: Possible ignition. CHROMYL CHLORIDE: Ignition. DIOXYGEN DIFLUORIDE: Possible explosion. DISULFURIC ACID AND NITRIC ACID: Possible ignition. DISULFURYL DIFLUORIDE: Violent reaction. FLUORINE NITRATE: Explosion. HYDROGEN PEROXIDE: Formation of highly explosive shock-sensitive compound. HYDROGEN PEROXIDE-SULFURIC ACID MIXTURE: Explosion. IODINE HEPTAFLUORIDE: Ignition. IODINE-MERCURIC OXIDE-METHYL ALCOHOL MIXTURE: Possible explosion. IODINE AND PHOSPHORUS: Formation of explosive ethane iodide. MANGANESE PERCHLORATE AND 2,2-DIMETHOXY PROPANE: Possible explosion. MERCURIC NITRATE: Formation of explosive compound. NITRIC ACID: Violent reaction. NITROSYL PERCHLORATE: Possible explosion. OXIDIZERS (STRONG): Fire and explosion hazard. PERCHLORATES: May form explosive compound when mixed. PERCHLORIC ACID: Explosion. PERMANGANIC ACID: Ignition or explosion. PERMANGANATES AND SULFURIC ACID: Explosion. PEROXYDISULFURIC ACID: Possible explosion. PHOSPHORUS(III) OXIDE: Ignition. PLATINUM: Ignition. POTASSIUM: Violent reaction. POTASSIUM DIOXIDE: Violent reaction, possible explosion. POTASSIUM PERCHLORATE: Possible explosion. POTASSIUM PERMANGANATE: Possible explosion. POTASSIUM TERT-BUTOXIDE: Ignition. RUTHENIUM(VIII) OXIDE: Formation of explosive compound. SILVER AND NITRIC ACID: Formation of explosive compound. SILVER NITRATE: Formation of explosive compound. SILVER PERCHLORATE: May form explosive compound when mixed. SODIUM-AIR: Possible explosion. SODIUM HYDRAZIDE: May cause violent explosion on contact. SODIUM PEROXIDE: Violent reaction. SULFURIC ACID AND SODIUM DICHROMATE: Possible explosion. TETRACHLOROSILANE: Violent reaction. URANIUM HEXAFLUORIDE: Violent reaction. URANYL PERCHLORATE: May form explosive compound when mixed. ALCOHOLS ACETALDEHYDE: Violent condensation reaction. BARIUM PERCHLORATE: Formation of highly explosive perchloric ester on refluxing. CHLORINE: Formation of highly explosive alkyl hypochlorites. DIETHYL ALUMINUM BROMIDE: Spontaneous ignition. ETHYLENE OXIDE: Possible explosion. HEXAMETHYLENE DIISOCYANATE: Possible explosion in absence of solvent. HYDROGEN PEROXIDE + SULFURIC ACID: Possible explosion. HYPOCHLOROUS ACID: Formation of highly explosive alkyl hypochlorites. ISOCYANATES: Possible explosion in absence of solvent. LITHIUM ALUMINUM HYDRIDE: Vigorous reaction. NITROGEN TETROXIDE: Possible explosion. PERCHLORIC ACID (HOT): Dangerous interaction. PERMONOSULFURIC ACID: Possible explosion on contact with primary or secondary alcohols. TRI-ISO-BUTYL ALUMINUM: Violent reaction. ISOPROPYL ALCOHOL: ACIDS: Incompatible. ACIDS ANHYDRIDES: Incompatible. ALUMINUM: Dissolution is exothermic. BARIUM PERCHLORATE: Formation of explosive compound. 2-BUTANONE (METHYL ETHYL KETONE): Accelerates the peroxidation of the alcohol. CHROMIUM TRIOXIDE (GRANULAR): Ignition. COATINGS: May be attacked. DIOXYGENYL TETRAFLUOROBORATE: Ignition at ambient temperatures. HALOGENS: Incompatible. HYDROGEN + PALLADIUM (PARTICLES): Ignition on exposure to air. HYDROGEN PEROXIDE: Formation of explosive compound. KETONES: Markedly increases the possibility of peroxidation. NITROFORM (TRINITROMETHANE): Dissolves liberating heat and possibly exploding. OLEUM: Temperature and pressure increase in closed container. OXIDIZERS (STRONG): Fire and explosion hazard. OXYGEN (GAS): Autoxidation, on exposure to light, results in formation of ketones and potentially explosive hydrogen peroxide. PHOSGENE: In the presence of iron salts, may explode. PLASTICS: May be attacked. POTASSIUM TERT-BUTOXIDE: Ignition. RUBBER: May be attacked. SODIUM DICHROMATE + SULFURIC ACID: Exothermic reaction with possible incandescence. See also ALCOHOLS. NITROMETHANE ACETONE: Explosion hazard. ACIDS: Explosion hazard. ALKYL METAL HALIDE: Ignites. ALUMINUM CHLORIDE + ORGANIC MATTER: Explosion hazard. ALUMINUM POWDER: Explosion hazard. AMINES: Explosion hazard. AMMONIUM SALTS + ORGANIC SOLVENTS: Explosion hazard. BASES: Explosion hazard. BIS(2-AMINOETHYL)AMINE: Explosion hazard. CALCIUM HYPOCHLORITE: Delayed, violent reaction. COPPER: Slowly corroded. COPPER ALLOYS: Incompatible. 1,2-DIAMINOETHANE + N,2,4,6-TETRANITRO-N-METHYL ANILINE: Forms explosive mixture. 1,2-DIAMINOMETHANE: Violent reaction. FORMALDEHYDE: Violent reaction. HALOFORMS: Explosion hazard. HEXAMETHYLBENZENE: Violent reaction. HYDRAZINE + METHANOL: Explosion hazard. HYDROCARBONS: Violent reaction. HYDROXIDES: Violent reaction. INORGANIC BASES: Forms explosive salts. LEAD AND LEAD ALLOYS: Incompatible. LITHIUM PERCHLORATE: Violent reaction. METAL OXIDES: Violent reaction. M-METHYL ANILINE: Violent reaction. NICKEL: May decompose. NITRIC ACID: Violent reaction. ORGANIC AMINES: Violent reactions. OXIDIZERS (STRONG): Fire and explosion hazard. SILVER NITRATE (AQUEOUS): Forms explosive silver fulminate. SILVER OXIDE + BORON TRIFLUORIDE ETHERATE: Potential violent explosion. STEEL + COPPER: Slowly corroded. SODIUM HYDRIDE: Violent reaction. URONIUM PERCHLORATE + ORGANIC MATERIALS: Explosion hazard. METHYL ALCOHOL ACETYL BROMIDE: Violent reaction with formation of hydrogen bromide. ALKYLALUMINUM SOLUTIONS: Violent reaction. ALUMINUM: Corrodes. BARIUM PERCHLORATE: Distillation yields highly explosive alkyl perchlorate. BERYLLIUM HYDRIDE: Violent reaction, even at -196 C. BROMINE: Vigorously exothermic reaction. CALCIUM CARBIDE: Violent reaction. CHLORINE: Possible ignition and explosion hazard. CHLOROFORM AND SODIUM HYDROXIDE: Explosive reaction. CHROMIUM TRIOXIDE (CHROMIC ANHYDRIDE): Possible ignition. CYANURIC CHLORIDE: Violent reaction. DICHLOROMETHANE: Possible ignition and explosion. DIETHYL ZINC: Possible ignition and explosion. HYDROGEN PEROXIDE + WATER: Explosion hazard. IODINE + ETHANOL + MERCURIC OXIDE: Explosion hazard. LEAD: Corrodes. LEAD PERCHLORATE: Explosion hazard. MAGNESIUM: Violent reaction. MAGNESIUM (POWDERED): Mixtures are capable of detonation. METALS: Incompatible. NICKEL: Possible ignition in the presence of nickel catalyst. NITRIC ACID (CONCENTRATED): Mixtures of greater than 25% acid may decompose violently. OXIDIZERS (STRONG): Fire and explosion hazard. PERCHLORIC ACID: Explosion hazard. PHOSPHOROUS TRIOXIDE: Possible violent reaction and ignition. PLASTICS, RUBBER, COATINGS: May be attacked. POTASSIUM: Possible dangerous reaction. POTASSIUM HYDROXIDE + CHLOROFORM: Exothermic reaction. POTASSIUM TERT-BUTOXIDE: Fire and explosion hazard. SODIUM + CHLOROFORM: Possible explosion. SODIUM HYPOCHLORITE: Explosion hazard. SODIUM METHOXIDE + CHLOROFORM: Violent reaction. SULFURIC ACID: Fire and explosion hazard. ZINC: Explosion hazard.

miscellaneous decomposition products 

Thermal decomposition products: miscellaneous decomposition products. 

Will not polymerize. Will not polymerize. 

Component Analysis - LD50/LC50 

Component Carcinogenicity

Human Sufficient Evidence IARC Group 1 Workers involved in the manufacture of isopropyl alcohol by the strong-acid process, involving the formation of isopropyl oils, showed an increase in paranasal and laryngeal cancer Inhalation studies show clear evidence of carcinogenic activity in mice and rats It increased the incidence of Harderian gland and lung tumors in both male and female mice as well as of hepatocellular adenomas in females In one experiment in rats, there was an increase in the incidence of benign and malignant mammary gland tumors in females. 

kidney disorders, eye disorders, central nervous system disorders, heart or cardiovascular disorders, convulsive disorders, liver disorders, kidney disorders, kidney disorders, heart problems, kidney disorders, respiratory disorders, skin disorders and allergies, liver disorders, respiratory disorders, liver disorders, skin disorders and allergies, skin disorders and allergies, respiratory disorders, skin disorders and allergies, 

May cross the placenta Stimulants such as epinephrine may induce ventricular fibrillation May be excreted in breast milk May cause blindness. 

Potentiates the effect of carbon tetrachloride and other hepatotoxic chlorinated aliphatic hydrocarbons Allergic reactions to alcohols have been reported. 

METHYL ALCOHOL: May cause irritation of the mucous membranes, coughing, oppression in the chest, tracheitis, bronchitis, tinnitus, unsteady gait, twitching, colic, constipation, nystagmus, and blepharospasm Symptoms from occupational exposure include paresthesias, numbness and shooting pains in the hands and forearms Metabolic acidosis, and effects on the eyes and central nervous system may occur as detailed in acute ingestion NITROMETHANE: Inhalation of 200 ppm may cause irritation of respiratory tract with coughing, difficulty breathing, possibly delayed, nausea, vomiting, diarrhea, and anorexia Central nervous system depression may occur with headache, dizziness, and narcosis Rabbits exposed to 10,000 ppm for 6 hours exhibited delayed symptoms of weakness, ataxia, muscular incoordination, convulsions and death Autopsy revealed focal necrosis of liver and moderate kidney damage Lower concentrations produced only mild irritation of the respiratory tract, narcosis and salivation Anesthesia and pulmonary edema have also been reported in animals ETHYL ALCOHOL: Exposure of humans to 1000-10,000 ppm has caused temporary irritation of the upper respiratory tract, coughing, and central nervous system depression with headache, stupor, fatigue, dizziness, drowsiness, dullness, lassitude, and loss of appetite A level of 20,000 ppm was considered just tolerable Above this level, the atmosphere was described as intolerable and suffocating, even brief exposures Additionally, exposure of animals to various concentrations has resulted in excitation followed by ataxia, incoordination, prostration, twitching, general paralysis, dyspnea, and occasionally death due to respiratory failure 1,1,2-TRICHLORO-1,2,2-TRIFLUOROETHANE: May cause mild irritation of the mucous membranes of the upper respiratory tract May be anesthetic and cause central nervous system depression with drowsiness and arrhythmias Humans exposed to 2500 to 4500 ppm for 30-100 minutes showed significant impairment of manual dexterity and vigilance, loss of concentration, somnolence and heaviness in the head, which disappeared 15 minutes after the exposure ended Simple asphyxiation may occur at high concentrations Overexposure could result in epinephine sensitization of the heart and subsequently may cause sudden death from ventricular fibrillation under physical or emotional stress Dogs exposed to 11,000-13,000 ppm for 6 hours experienced vomiting, lethargy, nervousness, and tremors All symptoms were reversible within 15 minutes In experimental animals, variable degrees of cardiodynamic effects that included tachycardia, myocardial depression, and hypotension have been reported Pulmonary edema and severe ventricular dysrhythmia may result from the inhalation of freons ISOPROPYL ALCOHOL: Human subjects exposed to 400 ppm for 3-5 minutes had mild irritation of the nose and throat At 800 ppm the irritation was not severe but uncomfortable Chest tightness and wheezing have also been reported in humans Higher concentrations may cause effects as detailed in acute ingestion The length of time required to produce deep narcosis in animals was inversely proportional to the concentration: The onset of deep narcosis ranged from 460 minutes at 3250 ppm to 100 minutes at 24,500 ppm.

NITROMETHANE: Animal studies indicate decreased body weight gain, thyroid and blood changes, and pulmonary abnormalities from exposure to 98-745 ppm for 10 days to 6 months Liver and kidney damage has been reported from repeated administration at levels >1000 ppm A dose as low as 1000 ppm produced death in one exposed monkey Studies in animals produced increased incidences of Harderian gland and lung tumors in both male and female mice as well as of hepatocellular adenomas in females Increased incidences of benign and malignant mammary gland tumors were also noted in female rats 1,1,2-TRICHLORO-1,2,2-TRIFLUOROETHANE: Prolonged human exposures for 2 weeks at concentrations of approximately 500 and 1000 ppm caused mild throat irritation on the first day, but no decrement in performance of complex mental tasks Pathologic findings in rats included very slight diffuse degenerative fatty infiltration of the liver No changes were produced in the offspring of pregnant rabbits exposed to 9 daily 2 hour exposures at levels as high as 20,000 ppm METHYL ALCOHOL: Repeated or prolonged exposure may cause effects as in acute ingestion Repeated exposure to 200-375 ppm caused recurrent headaches in workers Exposure for 4 years to 1200-8000 ppm resulted in marked diminution of vision and enlargement of the liver in a workman Reproductive effects have been reported in animals ISOPROPYL ALCOHOL: Mice subjected to 10900 ppm isopropyl alcohol in air for about 4 hours/day until they had accumulated 123 hours of exposure were narcotized but survived Reversible fatty changes were observed in the liver Male mice exposed to either 1000 or 5000 ppm of isopropyl alcohol vapor for 6 hours a day for 9 exposures exhibited hyaline droplet nephropathy Reproductive effects have been reported in animals There has been an increased incidence of cancer of the paranasal sinuses, and possibly of the larynx, in the manufacture of isopropyl alcohol by the strong acid process, involving the formation of isopropyl oils It is not clear which substances are responsible ETHYL ALCOHOL: Repeated or prolonged inhalation of vapors may cause irritation of the mucous membranes, headache, dizziness, nervousness, tremors, fatigue, nausea, narcosis, lack of concentration, and somnolence Tolerance may be a factor in individual response to a given air concentration Reproductive effects have been reported in animals.

ISOPROPYL ALCOHOL: Contact with the skin may cause slight irritation Contact dermatitis has been reported in a few sensitive individuals Substance may be dermally absorbed resulting in systemic toxicity as detailed in acute ingestion Toxic effects may become more marked if absorption and inhalation occur concurrently METHYL ALCOHOL: Contact with liquid may cause irritation Skin absorption may occur and cause metabolic acidosis and effects on the eyes and central nervous system as detailed in acute ingestion NITROMETHANE: Although some animal studies indicate no irritation, contact may cause drying of the skin with redness and irritation 1,1,2-TRICHLORO-1,2,2-TRIFLUOROETHANE: May cause irritation resulting in redness and pain ETHYL ALCOHOL: Direct contact may cause mild redness and burning Sensitization has occasionally been reported to occur in some individuals resulting in allergic contact dermatitis in the form of eczematous eruptions or, rarely, erythematous flush or contact urticaria at the exposed site Animal studies indicate that, depending on concentration and duration of exposure, varying degrees of irritation may occur ranging from mild to severe Skin absorption may also occur.

ETHYL ALCOHOL: Repeated or prolonged contact with the liquid can cause defatting of the skin, producing a dry, fissured dermatitis or other symptoms as in acute exposure A 21-day modified open Draize test resulted in no irritation in men, whereas an occlusive test resulted in erythema and induration toward the end of the exposure period 1,1,2-TRICHLORO-1,2,2-TRIFLUOROETHANE: Repeated or prolonged contact may cause dermatitis with drying and cracking due to defatting of the skin No effects were noted in rabbits after 20 weeks of application to uncovered skin However, occluded contact of 5 gm/kg with rabbit skin for 5 successive days resulted in local necrosis and sloughing, plus conspicuous enlargement of liver cells NITROMETHANE: Repeated or prolonged contact may cause a low-grade irritation and dermatitis ISOPROPYL ALCOHOL: Repeated or prolonged exposure to irritants may cause dermatitis due to the defatting action on the skin Repeated and prolonged exposure to the skin of rabbits caused slight erythema, drying, and superficial desquamation METHYL ALCOHOL: Repeated or prolonged contact with the liquid may cause defatting of the skin resulting in erythema, scaling, and eczematoid dermatitis Chronic absorption may result in metabolic acidosis and effects as detailed in acute ingestion.

ETHYL ALCOHOL: Vapor concentrations of 1,000-10,000 ppm may cause temporary eye irritation, with 15,000 ppm causing continuous tearing Direct contact with the liquid may cause immediate burning and stinging, with reflex closure of the lids, tearing, temporary injury of the corneal epithelium, and hyperemia of the conjunctiva Healing is usually spontaneous and complete Depending on the concentration, contact with the rabbit eyes causes a response ranging from mild irritation to severe injury Irrigation of rabbit eyes with a 10% solution for several minutes caused no serious disturbances ISOPROPYL ALCOHOL: May cause severe irritation with eye damage In rabbit eyes, a drop caused mild transitory injury and a 50% aqueous solution after 3 minutes caused moderate irritation Contact with a 70% solution caused conjunctivitis, iritis, and corneal opacity METHYL ALCOHOL: Vapors may cause irritation High concentrations have been reported to cause violent inflammation of the conjunctiva and epithelial defects on the cornea Mild irritation may occur with dilute solutions; the undiluted liquid has produced moderate corneal opacity and conjunctival redness in rabbits Application of a drop of methanol in rabbit eyes caused a mild reversible reaction, graded 3 on a scale of 1-10 after 24 hours NITROMETHANE: Although some animal studies indicate no irritation from contact, vapors have been reported to cause severe irritation at 500 ppm with pain and redness Corneal injury has also been reported 1,1,2-TRICHLORO-1,2,2-TRIFLUOROETHANE: May cause irritation resulting in redness and pain Application of 0.1 ml to rabbit eyes is reported to have produced only mild conjunctivitis and minimal corneal dullness at 24 hours All eyes returned to normal within 48 hours.

ETHYL ALCOHOL: Repeated or prolonged contact with irritants may cause conjunctivitis Repeated application to rabbit eyes of 40-80% solutions caused corneal cloudiness, conjunctival necrosis, and loss of corneal epithelium and endothelium This may be followed by conjunctival hemorrhaging and edema, and infiltration and vascularization of the corneal stroma ISOPROPYL ALCOHOL: Repeated or prolonged exposure to irritants may cause conjunctivitis METHYL ALCOHOL: Repeated or prolonged contact may cause conjunctivitis NITROMETHANE: No data available 1,1,2-TRICHLORO-1,2,2-TRIFLUOROETHANE: Repeated or prolonged contact may cause conjunctivitis.

1,1,2-TRICHLORO-1,2,2-TRIFLUOROETHANE: Large doses may cause gastrointestinal irritation If sufficient amounts are ingested, systemic toxicity may occur as detailed in acute inhalation METHYL ALCOHOL: May cause mild and transient inebriation and subsequent drowsiness followed by an asymptomatic period lasting 8-48 hours Following the delay, coughing, dyspnea, headache, dullness, weakness, vertigo or dizziness, nausea, vomiting, occasional diarrhea, anorexia, violent pain in the back, abdomen, and extremities, restlessness, apathy or delirium, and rarely, excitement and mania may occur Rapid, shallow respiration due to metabolic acidosis, cold and clammy skin, hypotension, cyanosis, opisthotonos, convulsions, mild tachycardia, cardiac depression, peripheral neuritis, cerebral and pulmonary edema, unconsciousness, and coma are possible Effects on the eye may include optic neuritis, blurred or dimmed vision, dilated, unresponsive pupils, ptosis, eye pain, concentric constriction of visual fields, diplopia, change in color perception, photophobia, and optic nerve atrophy Partial blindness or possibly delayed transient or permanent blindness may occur Bilateral sensorineural deafness has been reported in a single case Liver, kidney, heart, stomach, intestinal and pancreatic damage may also occur Death may be due to respiratory failure or rarely from circulatory collapse As little as 15 ml has caused blindness; the usual fatal dose is 60-240 ml Prolonged asthenia and irreversible effects on the nervous system including difficulty in speech, motor dysfunction with rigidity, spasticity, and hypokinesis have been reported ETHYL ALCOHOL: Ingestion may cause emotional lability and decreased inhibitions, with exhilaration, boastfulness, talkativeness, remorse, and belligerency This may be followed by gradual visual impairment, muscular incoordination, slowing of reaction time, sensory disturbances, and slurring of speech Other symptoms may include flushing of the face, dilated pupils, rapid pulse, nausea, vomiting, sweating, and diuresis Ingestion of large amounts may cause confusion, disorientation, loss of motor nerve control, shallow respiration, involuntary defecation and urination, drowsiness, stupor, and possibly coma Convulsions due to hypoglycemia and shock with hypotension, tachycardia, cold pale skin, hypothermia, respiratory depression, and decreased reflexes may occur Death may occur from respiratory or circulatory failure or later from aspiration pneumonitis or pulmonary edema Recovery may be accompanied by headache, insomnia, gastritis, infection, restlessness, psychoses with uncontrollable fear, and visual, auditory, or gustatory hallucinations, exaggerated reflexes, tachycardia, and convulsions Some individuals sensitized by external contact may suffer from a generalized erythema, stomatitis, urticaria, angioedema, morbilliform eruptions, or eczematous dermatitis at sites previously affected by external contact Reproductive effects have been reported in animals ISOPROPYL ALCOHOL: Ingestion may cause gastrointestinal irritation with abdominal pain, hematemesis, nausea, vomiting, and hemorrhage Central nervous system depression may occur with headache, dizziness, flushing, incoordination, hallucinations, stupor, confusion, hypotension, areflexia, and refractory narcosis Oliguria followed by diuresis and coma may also occur Other symptoms may include hypoglycemia, tenderness and edema of muscles, arrhythmias, decrease in pulse rate, lower blood pressure, and anesthesia Depressed respiration and death due to respiratory paralysis may occur in a few hours after exposure Severe and prolonged shock may lead to serious or fatal renal damage after several days Pathologic findings have included extensive hemorrhagic tracheobronchitis, bronchopneumonia and hemorrhagic pulmonary edema NITROMETHANE: Ingestion may cause gastrointestinal irritation, abdominal pain, and nausea Central nervous system depression with both atactic and narcotic changes has been reported.

1,1,2-TRICHLORO-1,2,2-TRIFLUOROETHANE: No changes were produced in the offspring of pregnant rabbits exposed orally METHYL ALCOHOL: Repeated ingestion may cause visual impairment and blindness and other systemic effects as detailed in acute ingestion Reproductive effects have been reported in animals ETHYL ALCOHOL: Chronic intoxication may result in weight loss, degenerative changes in the liver, kidneys, and brain, gastroenteritis with anorexia and diarrhea, and cirrhosis of the liver Polyneuritis with pain, motor and sensory loss in the extremities, and optic atrophy may occur Amnesia, tremors, confusion, impaired judgement, and loss or impairment of mental abilities are possible Many years of chronic ingestion have caused acute myopathy with tenderness, aching, edema, and degeneration of the muscles The heart may be affected, causing palpitations, extrasystole, tachycardia, or other arrhythmias, which may progress to irreversible myocardial fibrosis and circulatory failure ISOPROPYL ALCOHOL: No adverse effects resulted in humans following daily ingestion of 2.6 and 6.4 mg/kg for 6 weeks Rats that ingested 0.5 to 10.0% isopropyl alcohol in drinking water for 27 weeks showed decreased body weight Prolonged oral administration in rabbits produced anesthesia and death Reproductive effects have been reported in animals NITROMETHANE: Some rats and dogs exposed to 0.1% to 0.25% in drinking water for up to 15 weeks died Survivors showed slower weight gain Pathological changes in the liver were found in animals receiving the 0.25% dose.

Component Analysis - Aquatic Toxicity 

Bioconcentration Factor 

Dispose in accordance with all applicable regulations. 

Component Waste Numbers 

ADR Tunnel Code Restrictions 

Component Marine Pollutants (IMDG) 

SARA Section 311/312 (40 CFR 370 Subparts B and C) 

The following statement(s) are provided under the California Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65): 

Canadian WHMIS Ingredient Disclosure List (IDL) 

Germany Water Classification 

REACH List of Substances on Community Rolling Action Plan - Reg. (EU) No. 1907/2006 

The listed component(s) of this material have been checked for country-specific published classifications according to the Globally Harmonized System of Classification and Labeling (GHS). The results of the queries are displayed below. Please see the individual country listings, as additional interpretations or reference information may be available. For a reference list of H- or P-statements, please visit ChemADVISOR’s website at http://www.chemadvisor.com/product-resources/26-pure-substance-and-mixture-databases/247-ghs-hazard-and-physical-statements 

Australia GHS Classifications 

Australia GHS Labeling Information 

European Union GHS Classifications 

European Union GHS Labeling Information 

Indonesia GHS Classifications 

Japan GHS Classifications 

Japan GHS Labeling Information 

Korea GHS Classifications 

Korea GHS Labeling Information 

New Zealand GHS Classifications 

New Zealand GHS Labeling Information 

South Africa GHS Classifications 

Taiwan GHS Classifications 

Taiwan GHS Labeling Information 

No classification assigned. 

ACGIH - American Conference of Governmental Industrial Hygienists; ADR - European Road Transport; AU - Australia; BOD - Biochemical Oxygen Demand; C - Celsius; CA - Canada; CAS - Chemical Abstracts Service; CERCLA - Comprehensive Environmental Response, Compensation, and Liability Act; CN - China; CPR - Controlled Products Regulations; DFG - Deutsche Forschungsgemeinschaft; DOT - Department of Transportation; DSL - Domestic Substances List; EEC - European Economic Community; EINECS - European Inventory of Existing Commercial Chemical Substances; EPA - Environmental Protection Agency; EU - European Union; F - Fahrenheit; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; ICAO - International Civil Aviation Organization; IDL - Ingredient Disclosure List; IDLH - Immediately Dangerous to Life and Health; IMDG - International Maritime Dangerous Goods; JP - Japan; Kow - Octanol/water partition coefficient; KR - Korea; LEL - Lower Explosive Limit; LOLI - List Of LIsts™ - ChemADVISOR’s Regulatory Database; MAK - Maximum Concentration Value in the Workplace; MEL - Maximum Exposure Limits; NFPA - National Fire Protection Agency; NIOSH - National Institute for Occupational Safety and Health; NJTSR - New Jersey Trade Secret Registry; NTP - National Toxicology Program; NZ - New Zealand; OSHA - Occupational Safety and Health Administration; PH - Philippines; RCRA - Resource Conservation and Recovery Act; RID - European Rail Transport; RTECS - Registry of Toxic Effects of Chemical Substances®; SARA - Superfund Amendments and Reauthorization Act; STEL - Short-term Exposure Limit; TDG - Transportation of Dangerous Goods; TSCA - Toxic Substances Control Act; TWA - Time Weighted Average; UEL - Upper Explosive Limit; US - United States 

Reasonable care has been taken in the preparation of this information; however, the manufacturer makes no warranty whatsoever including the warranty of merchantability, expressed or implied, with respect to this information. The manufacturer makes no representations and assumes no liability for any direct, incidental, consequential, or other such damages resulting from its use or misuse. 

Supplier gives no warranty whatsoever, including the warranties of merchantability or of fitness for a particular purpose. Any product purchased is sold on the assumption the purchaser shall determine the quality and suitability of the product. Supplier expressly disclaims any and all liability for incidental, consequential or any other damages arising out of the use or misuse of this product. No information provided shall be deemed to be a recommendation to use any product in conflict with any existing patent rights. THIS SDS IS TO BE UTILIZED SOLELY AS A REFERENCE DOCUMENT AND IT IS NOT TO BE USED TO SATISFY THE DISTRIBUTION REQUIREMENTS OF OSHA'S HAZARD COMMUNICATION STANDARD (HCS) NOR CANADA'S CONTROLLED PRODUCT REGULATION (CPR). Read the Safety Data Sheet before handling product. Use of any information contained herein is provided at the reader's own risk and thus independent judgment by trained professionals must be utilized at all times. 

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