CHLORDIMEFORM HYDROCHLORIDE

halogenated, aromatic, amidines 

45639-81

Emergency Overview 

Change in color: Not available

Physical Form: technical chemical

Health Hazards:  harmful if swallowed 

Short Term:  same as effects reported in long term exposure, nausea, vomiting 

Long Term:  rash, drowsiness, dizziness 

Short Term:  mild irritation 

Long Term:  rash, drowsiness, dizziness 

Short Term:  mild irritation 

Long Term:  no information is available 

Short Term:  no information on significant adverse effects 

Long Term:  bluish skin color, blood disorders 

If adverse effects occur, remove to uncontaminated area. Give artificial respiration if not breathing. Get immediate medical attention. 

Wash skin with soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention, if needed. Thoroughly clean and dry contaminated clothing and shoes before reuse. 

Flush eyes with plenty of water for at least 15 minutes. Then get immediate medical attention. 

Get medical attention immediately. 

For ingestion, consider gastric lavage and catharsis. Consider oxygen. 

See Section 9 for Flammability Properties 

Slight fire hazard. 

regular dry chemical, regular foam, water Large fires: Use regular foam or flood with fine water spray. 

Move container from fire area if it can be done without risk. Fight large fires from a protected location or safe distance. Stay away from the ends of tanks. Dike for later disposal. Do not scatter spilled material with high-pressure water streams. Do not attempt to extinguish fire unless flow of material can be stopped first. Use extinguishing agents appropriate for surrounding fire. Flood with fine water spray. Cool containers with water spray until well after the fire is out. Apply water from a protected location or from a safe distance. Avoid inhalation of material or combustion by-products. Stay upwind and keep out of low areas. Consider downwind evacuation if material is leaking. 

Do not touch spilled material. Stop leak if possible without personal risk. Reduce vapors with water spray. Small spills: Absorb with sand or other non-combustible material. Collect spilled material in appropriate container for disposal. Small dry spills: Move containers away from spill to a safe area. Large spills: Dike for later disposal. Keep unnecessary people away, isolate hazard area and deny entry. Ventilate closed spaces before entering. 

Store and handle in accordance with all current regulations and standards. May be subject to EPA pesticide registration. 

Component Exposure Limits 

Biological limit value 

Provide local exhaust ventilation system. Ensure compliance with applicable exposure limits. 

Eyes/Face Wear splash resistant safety goggles. Provide an emergency eye wash fountain and quick drench shower in the immediate work area. 

Wear appropriate chemical resistant clothing. 

Wear appropriate chemical resistant gloves. 

Under conditions of frequent use or heavy exposure, respiratory protection may be needed. Respiratory protection is ranked in order from minimum to maximum. Consider warning properties before use. Any air-purifying half-mask respirator equipped with organic vapor cartridge(s) in combination with an N95, R95, or P95 filter. The following filters may also be used: N99, R99, P99, N100, R100 or P100. Any air-purifying full-facepiece respirator (gas mask) with a chin-style, front-mounted or back-mounted organic vapor canister having an N100, R100, or P100 filter. Any powered, air-purifying respirator with a tight-fitting facepiece, organic vapor cartridge(s) and high-efficiency particulate filter(s). Any supplied-air respirator with a full facepiece that is operated in a pressure-demand or other positive-pressure mode. For Unknown Concentrations or Immediately Dangerous to Life or Health - Any supplied-air respirator with a full facepiece that is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode. Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. 

Stable at normal temperatures and pressure. Stable at normal temperatures and pressure. 

CHLORDIMEFORM HYDROCHLORIDE No data available.

phosgene, halogenated compounds, oxides of carbon 

Thermal decomposition products: phosgene, chlorides, oxides of carbon. 

Will not polymerize. Will not polymerize. 

Component Analysis - LD50/LC50 

Component Carcinogenicity

None of this product's components are listed by ACGIH, IARC, NTP, DFG or OSHA

The available data are insufficient to evaluate the carcinogenicity of chlordimeform to humans However, results of experiments in mice provide sufficient evidence that para-chloro-ortho-toluidine, a metabolite of chlordimeform, is carcinogenic to experimental animals. 

CHLORDIMEFORM HYDROCHLORIDE: May cause nausea, vomiting and lethargy Massive exposure to chlordimeform may cause effects as listed in chronic exposure.

CHLORDIMEFORM HYDROCHLORIDE: Symptoms of increase urinary frequency, gross hematuria, urethral discharge, abdominal and back pain, and a hot sensation all over were reported among workers exposed to chlordimeform Other effects of bladder irritation, sleepiness, skin rash, anorexia, dizziness, and a sweet taste in the mouth also occurred An urological examination of three hospitalized workers revealed hematuria and pyuria, proteinuria, low creatinine clearance, decreased serum complement level, elevated serum glutamic oxaloacetic transaminase, small urinary bladder capacity and ureteral reflux; severe hemorrhagic cystitis was determined by cystoscopic examination These effects were completely reversed within a three to eight week period.

CHLORDIMEFORM HYDROCHLORIDE: This material was slightly irritating to the skin of rabbits A lethal dose by dermal absorption in rabbits was 4000 mg/kg A lethal dose of a metabolite of chlordimeform, 4-chloro-o-toluidine, produced hemorrhage of the bladder mucosa in cats; a condition that is not produced by chlordimeform or its metabolites in other animals.

CHLORDIMEFORM HYDROCHLORIDE: Symptoms of increase urinary frequency, gross hematuria, urethral discharge, abdominal and back pain, and a hot sensation all over were reported among workers exposed to chlordimeform Other effects of bladder irritation, sleepiness, skin rash, anorexia, dizziness, and a sweet taste in the mouth also occurred An urological examination of three hospitalized workers revealed hematuria and pyuria, proteinuria, low creatinine clearance, decreased serum complement level, elevated serum glutamic oxaloacetic transaminase, small urinary bladder capacity and ureteral reflux; severe hemorrhagic cystitis was determined by cystoscopic examination These effects were completely reversed within a three to eight week period.

CHLORDIMEFORM HYDROCHLORIDE A 100 mg applied to the eyes of rabbits was mildly irritating.

CHLORDIMEFORM HYDROCHLORIDE No data available.

CHLORDIMEFORM HYDROCHLORIDE A lethal dose in rat was 225 mg/kg.

CHLORDIMEFORM HYDROCHLORIDE: Effects of reduced food consumption, decreased blood glucose, hemolytic anemia and blood vessel neoplasms was observed in studies of mice repeatedly fed chlordimeform hydrochloride In rats studies, effects from repeated administration of this material included reduced food consumption and body weights, decreased overnight urine, decreased blood glucose, and increased methemoglobin formation In a lifetime feeding study of mice, hemangioendothelioma (a cancer derived from blood vessels) was observed at dietary levels of 100 and 500 ppm; no oncogenic effects were reported in rats at these levels Para-chloro-ortho-toluidine, a metabolite of chlordimeform, produced carcinogenic effects in mice.

Component Analysis - Aquatic Toxicity 

May be subject to EPA pesticide registration. 

Component Waste Numbers 

Component Marine Pollutants (IMDG) 

SARA Section 311/312 (40 CFR 370 Subparts B and C) 

Not listed under California Proposition 65 

The listed component(s) of this material have been checked for country-specific published classifications according to the Globally Harmonized System of Classification and Labeling (GHS). The results of the queries are displayed below. Please see the individual country listings, as additional interpretations or reference information may be available. For a reference list of H- or P-statements, please visit ChemADVISOR’s website at http://www.chemadvisor.com/product-resources/26-pure-substance-and-mixture-databases/247-ghs-hazard-and-physical-statements 

Australia GHS Classifications 

Australia GHS Labeling Information 

European Union GHS Classifications 

European Union GHS Labeling Information 

Indonesia GHS Classifications 

Japan GHS Classifications 

Japan GHS Labeling Information 

Korea GHS Classifications 

New Zealand GHS Classifications 

South Africa GHS Classifications 

Taiwan GHS Classifications 

Taiwan GHS Labeling Information 

No classification assigned. 

ACGIH - American Conference of Governmental Industrial Hygienists; ADR - European Road Transport; AU - Australia; BOD - Biochemical Oxygen Demand; C - Celsius; CA - Canada; CAS - Chemical Abstracts Service; CERCLA - Comprehensive Environmental Response, Compensation, and Liability Act; CN - China; CPR - Controlled Products Regulations; DFG - Deutsche Forschungsgemeinschaft; DOT - Department of Transportation; DSL - Domestic Substances List; EEC - European Economic Community; EINECS - European Inventory of Existing Commercial Chemical Substances; EPA - Environmental Protection Agency; EU - European Union; F - Fahrenheit; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; ICAO - International Civil Aviation Organization; IDL - Ingredient Disclosure List; IDLH - Immediately Dangerous to Life and Health; IMDG - International Maritime Dangerous Goods; JP - Japan; Kow - Octanol/water partition coefficient; KR - Korea; LEL - Lower Explosive Limit; LOLI - List Of LIsts™ - ChemADVISOR’s Regulatory Database; MAK - Maximum Concentration Value in the Workplace; MEL - Maximum Exposure Limits; NFPA - National Fire Protection Agency; NIOSH - National Institute for Occupational Safety and Health; NJTSR - New Jersey Trade Secret Registry; NTP - National Toxicology Program; NZ - New Zealand; OSHA - Occupational Safety and Health Administration; PH - Philippines; RCRA - Resource Conservation and Recovery Act; RID - European Rail Transport; RTECS - Registry of Toxic Effects of Chemical Substances®; SARA - Superfund Amendments and Reauthorization Act; STEL - Short-term Exposure Limit; TDG - Transportation of Dangerous Goods; TSCA - Toxic Substances Control Act; TWA - Time Weighted Average; UEL - Upper Explosive Limit; US - United States 

Reasonable care has been taken in the preparation of this information; however, the manufacturer makes no warranty whatsoever including the warranty of merchantability, expressed or implied, with respect to this information. The manufacturer makes no representations and assumes no liability for any direct, incidental, consequential, or other such damages resulting from its use or misuse. 

Supplier gives no warranty whatsoever, including the warranties of merchantability or of fitness for a particular purpose. Any product purchased is sold on the assumption the purchaser shall determine the quality and suitability of the product. Supplier expressly disclaims any and all liability for incidental, consequential or any other damages arising out of the use or misuse of this product. No information provided shall be deemed to be a recommendation to use any product in conflict with any existing patent rights. THIS SDS IS TO BE UTILIZED SOLELY AS A REFERENCE DOCUMENT AND IT IS NOT TO BE USED TO SATISFY THE DISTRIBUTION REQUIREMENTS OF OSHA'S HAZARD COMMUNICATION STANDARD (HCS) NOR CANADA'S CONTROLLED PRODUCT REGULATION (CPR). Read the Safety Data Sheet before handling product. Use of any information contained herein is provided at the reader's own risk and thus independent judgment by trained professionals must be utilized at all times. 

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